Yohimbe Bark Extract | Pausinystalia johimbe | Yohimbine

Product Name: Yohimbe Bark Extract (Pausinystalia johimbe)
Source: Bark of Pausinystalia johimbe
Primary Alkaloid: Yohimbine (C₂₁H₂₆N₂O₃) – complex indole alkaloid with four rings and a side chain
Standardized Yohimbine Content: 1–2% (USP/NF)
Appearance: Light yellow to brown powder
Solubility: Freely soluble in organic solvents (ethanol, methanol); moderately soluble in water

1. Introduction

Yohimbe bark extract is standardized to the alkaloid yohimbine. Yohimbine is an α₂-adrenergic blocker that stimulates peripheral circulation, improves erectile function, and promotes lipolysis.

In traditional African medicine, yohimbe has been used as an aphrodisiac. In pharmacology, the extract is used for erectile dysfunction and in sports nutrition as a fat burner.

2. Production

Extraction by percolation or maceration of bark in ethanol/methanol, filtration, evaporation, and drying; standardization based on yohimbine content (1–2%).

3. Properties

• Appearance: Light yellow to brown powder

• Solubility: Freely soluble in organic solvents (ethanol, methanol); moderately soluble in water

• Standardized yohimbine content: 1–2% (USP/NF)

4. Applications

• Pharmaceuticals for erectile dysfunction treatment – yohimbine 5–10 mg three times daily

• Sports nutrition and fat burners – lipolysis stimulation

• Combinations with antidepressants and vascular agents for synergistic effects

5. Conclusion

Yohimbe bark extract is a potent agent with pronounced adrenergic blocking action. Caution is required in cases of hypertension, cardiovascular disorders, and psychiatric conditions.