Tocophersolan (Vitamin E TPGS) | CAS 9002-96-4

Product Name: Tocophersolan (INN)
CAS No.: 9002-96-4
Synonyms: d-alpha-Tocopheryl polyethylene glycol succinate; Tocofersolan; Tocopherolsolane
Appearance: Clear, colorless solid
Assay (D-α-tocopherol): 25.0% min
Density: 1.01 g/cm³
Boiling Point: 662.7 °C at 760 mmHg
Melting Point: 34–38 °C
Flash Point: 195.4 °C
Refractive Index: 1.496
Stability: Stable under normal temperatures and pressures
Storage Conditions: 2–8 °C

Safety Information
WGK Germany: 2
RTECS: TR1581200

Description

Tocophersolan (INN), also known as TPGS, is a synthetic water-soluble form of vitamin E. While natural forms of vitamin E are fat-soluble and insoluble in water, tocophersolan is a polyethylene glycol (PEG) derivative of α-tocopherol that provides water solubility.

Pharmaceutical Use

Tocophersolan is used as a vitamin E supplement or for the treatment of vitamin E deficiency in patients who cannot absorb fats due to disease. On July 24, 2009, the European Medicines Agency (EMA) approved tocophersolan under the trade name Vedrop® as an oral solution (50 mg/mL) for treating vitamin E deficiency caused by fat malabsorption in children aged from birth (full-term newborns) to 16 or 18 years (depending on the region) with congenital or hereditary chronic cholestasis.

Cosmetic and Other Applications

Tocophersolan is also used in cosmetics and pharmaceuticals as an antioxidant.