Vitamin K2 MK-7 (Menaquinone-7) | Bone & Vascular Health

Product Name: Vitamin K2 MK-7 (Menaquinone-7)
Molecular Formula: C₄₆H₆₄O₂
Structure: 2-methyl-1,4-naphthoquinone with seven isoprene units in the side chain
Appearance: Yellow crystalline powder
Solubility: Insoluble in water; soluble in lipids and organic solvents
Stability: Stable in lipid media; sensitive to oxygen and light

1. Introduction

Vitamin K2 MK-7 (Menaquinone-7) is a fat-soluble coenzyme involved in the γ-carboxylation of proteins responsible for bone mineralization and vascular calcium regulation. It has a long half-life and high oral bioavailability.

Vitamin K2 includes long-chain menaquinones; MK-7 is the most studied form. It is produced by bacteria (natto culture B. subtilis) and is absorbed longer than vitamin K1. Its deficiency is associated with osteoporosis and vascular calcification.

2. Production

Industrial production is achieved through bacterial fermentation of natto strains, followed by solvent extraction and chromatography.

3. Properties

• Appearance: Yellow crystalline powder

• Solubility: Insoluble in water; soluble in lipids and organic solvents

• Stability: Stable in lipid media; sensitive to oxygen and light

4. Applications

• Nutraceuticals: Capsules for bone and vascular support

• Pharmaceuticals: Osteoporosis prevention, adjunct for cardiovascular diseases

• Pediatrics and gerontology: Regulation of mineralization in children and the elderly

5. Conclusion

MK-7 is an effective form of vitamin K2 with long-lasting action and high bioavailability. Optimal dosages for the prevention of osteoporosis and vascular disorders without the risk of excessive prothrombotic effects are being investigated.