Vitamin B7 (Biotin) | Coenzyme for Carboxylases

Product Name: Vitamin B7 (Biotin)
Molecular Formula: C₁₀H₁₆N₂O₃S
Structure: Five-ring system – thiolane ring (containing S) and ureido ring
Appearance: Yellowish crystals or powder
Solubility: Soluble in water and dilute acids
Stability: Relatively stable at pH 4–8; degrades at high temperatures and under UV radiation

1. Introduction

Biotin (Vitamin B7) is a water-soluble coenzyme for carboxylases involved in carbohydrate, lipid, and amino acid metabolism. It promotes skin, hair, and nail health and supports energy metabolism and normal nervous system function.

Biotin is essential for the carboxylation of pyruvate, acetyl-CoA, and propionyl-CoA in the Krebs cycle and gluconeogenesis. Deficiency causes dermatitis, alopecia, and neurological disorders. It is obtained from dietary sources and gut microbiota.

2. Production

Industrial production – microbiological fermentation and chemical synthesis/modification followed by purification.

3. Properties

• Appearance: Yellowish crystals or powder

• Solubility: Soluble in water and dilute acids

• Stability: Relatively stable at pH 4–8; degrades at high temperatures and under UV radiation

4. Applications

• Dietetics: Vitamin complexes for skin, hair, and nails

• Pharmaceuticals: Metabolic support for diabetes and neuropathies

• Pediatrics: Prevention of birth defects in pregnant women

5. Conclusion

Biotin is an essential carboxylase coenzyme and an important nutrient for maintaining metabolism and skin health. The daily requirement is safe and well tolerated; deficiency is rare with a balanced diet.