Vitamin B12 (Cyanocobalamin) | CAS 68-19-9 | Essential

Product Name: Vitamin B12 (Cyanocobalamin)
CAS No.: 68-19-9
Molecular Formula: C₆₃H₈₈CoN₁₄O₁₄P
Structure: Corrin ring centered with Co³⁺, axially coordinated with cyanide
Appearance: Red-orange crystals
Solubility: 0.2 g/L in water; stable in acidic environments
Sensitivity: Degrades under alkaline pH; metabisulfite is added to prevent decomposition

1. Introduction

Cyanocobalamin is a synthetic form of vitamin B12 containing a cobalamin core with a coordinated cyanide anion. It is essential for DNA synthesis, hematopoiesis, and nervous system function.

Vitamin B12 is synthesized only by microorganisms. Deficiency causes megaloblastic anemia, neuropathies, and cognitive impairment. Oral and injectable use is necessary for malabsorption conditions (atrophic gastritis, cystic fibrosis).

2. Production

Microbiological fermentation of Propionibacterium shermanii, extraction, and chemical conversion to cyanocobalamin.

3. Properties

• Appearance: Red-orange crystals

• Solubility: 0.2 g/L in water; stable in acidic environments

• Sensitivity: Degrades under alkaline pH; metabisulfite is added to prevent decomposition

4. Applications

• Pharmaceuticals: Preparations for vitamin B12 hypovitaminosis correction, pernicious anemia

• Dietetics: Vegan supplements

• Neuropathy therapy: Enhancement of the myelin sheath of nerves

5. Conclusion

Cyanocobalamin is an essential vitamin coenzyme, key for hematopoiesis and neuronal metabolism. The issue of optimizing delivery and overcoming absorption barriers remains relevant.