Rutin (Rutoside) | Flavonoid | Vascular Health | CAS 153-18-4

Product Name: Rutin (Rutoside)
CAS No.: 153-18-4
Molecular Formula: C₂₇H₃₀O₁₆
Structure: Quercetin glycosylated with disaccharide (rutinose) at position 3 (3-O-rutinoside)
Appearance: Yellow crystalline powder
Melting Point: 210–215 °C (with decomposition)
Solubility: Approximately 0.125 g/L in water at 20 °C; freely soluble in hot water, ethanol, and DMSO
Stability: Light- and heat-sensitive; requires protection from UV and moisture

1. Introduction

Rutin is a flavonoid glycoside (quercetin-3-O-rutinoside) with pronounced antioxidant, angioprotective, and anti-inflammatory properties. It reduces capillary permeability and fragility, protecting plasma lipids from oxidation.

Rutin is extracted from buckwheat, citrus fruits, and eucalyptus leaves. In medicine and nutraceuticals, it is used to strengthen blood vessels and prevent varicose veins and edema.

2. Production

Obtained by extraction from plant materials (70–80% ethanol), followed by chromatographic purification. Chemical synthesis involves glycosylation of quercetin with rutinose using activated sugars.

3. Properties

• Appearance: Yellow crystalline powder

• Melting Point: 210–215 °C (with decomposition)

• Solubility: Approximately 0.125 g/L in water at 20 °C; freely soluble in hot water, ethanol, and DMSO

• Stability: Light- and heat-sensitive; requires protection from UV and moisture

4. Applications

• Vascular pathologies: Venotonics for varicose veins and hemorrhoids

• Antioxidant therapy: Supplements for protection against oxidative stress

• Cosmetology: Strengthening capillary blood flow in skin tissues

5. Conclusion

Rutin is an effective natural flavonoid for vascular protection and strengthening. Optimal dosages in nutraceuticals are 500–1000 mg/day, standardized to ≥95% rutin.