Rapamycin (Sirolimus) | CAS 53123-88-9 | mTOR Inhibitor

Product Name: Rapamycin (Sirolimus)
CAS No.: 53123-88-9
Molecular Formula: C₅₁H₇₉NO₁₃
Appearance: White to slightly cream-colored crystalline powder
Solubility: Poorly soluble in water; requires solvents or salt forms for injectable preparations
Stability: Good stability when protected from light and high humidity

1. Introduction

Rapamycin (Sirolimus) is a macrolide antibiotic that inhibits mTOR, possessing immunosuppressive and antitumor properties. The drug is used for transplant rejection prophylaxis and in research aimed at lifespan extension and cancer treatment.

Rapamycin was originally discovered as an antibiotic, but its ability to inhibit mTOR, a key regulator of cell growth, has significantly expanded its range of applications. Today, it is used in transplantology and in research targeting age-related and oncological pathologies.

2. Chemical Structure & Synthesis

Rapamycin is a complex macrolide compound primarily obtained by fermentation of Streptomyces hygroscopicus strains. Modern synthesis and structural modification methods allow for improvement of its pharmacokinetic properties.

3. Properties

• Appearance: White to slightly cream-colored crystalline powder

• Solubility: Poorly soluble in water; requires solvents or salt forms for injectable preparations

• Stability: Good stability when protected from light and high humidity

4. Applications

Rapamycin is widely used in transplantology for organ rejection prophylaxis. It is also being studied as a drug for certain types of cancer and for lifespan extension through its effect on the mTOR signaling pathway.

5. Conclusion

Rapamycin is a promising macrolide that inhibits mTOR, with proven efficacy in immunosuppressive and antitumor therapy. Its potential in regulating aging and longevity continues to generate great interest in the scientific community.