Potassium Magnesium Aspartate | CAS 11103-54-9 | Electrolyte Corrector
Product Name: Potassium Magnesium Aspartate
CAS No.: 11103-54-9
Appearance: White crystalline powder or granules, odorless
Solubility: Freely soluble in water
Bioavailability: Aspartic acid facilitates active transport of K⁺ and Mg²⁺ across cell membranes
1. Introduction
Potassium magnesium aspartate is a combination drug containing aspartate salts of potassium and magnesium. It is used to correct deficiencies of these important macroelements in the body, as well as in the complex therapy of cardiovascular diseases such as coronary artery disease, heart failure, and arrhythmias. Aspartic acid acts as a transport agent, facilitating the penetration of potassium and magnesium ions into cells.
Potassium and magnesium ions play a key role in many physiological processes, including maintaining cell membrane potential, conducting nerve impulses, muscle contraction (including cardiac muscle), and participating in numerous enzymatic reactions. Deficiency of these ions can lead to serious disorders of the cardiovascular, nervous, and muscular systems. Preparations based on potassium and magnesium aspartate are aimed at replenishing this deficiency and normalizing electrolyte balance.
2. Chemical Structure & Synthesis
Potassium magnesium aspartate is a mixture of aspartic acid salts with potassium and magnesium ions. The formulas of potassium and magnesium aspartate (anhydrous form) can be represented as follows:
| Component | Formula |
|---|---|
| Potassium Aspartate | C₄H₆KNO₄ |
| Magnesium Aspartate | Mg(C₄H₅NO₄)₂ |
Pharmaceutical preparations often use potassium aspartate hemihydrate and magnesium aspartate tetrahydrate. Synthesis is carried out by reacting aspartic acid with the corresponding potassium and magnesium hydroxides or carbonates, followed by crystallization.
3. Physicochemical Properties & Pharmacology
| Property | Description |
|---|---|
| Appearance | White crystalline powder or granules, odorless |
| Solubility | Freely soluble in water |
| Bioavailability | Aspartic acid promotes active transport of K⁺ and Mg²⁺ across cell membranes |
Pharmacological Action:
| Ion | Role |
|---|---|
| Potassium (K⁺) | Maintains normal cell membrane function; nerve impulse conduction; skeletal and smooth muscle contraction; cardiac rhythm regulation |
| Magnesium (Mg²⁺) | Cofactor for many enzymatic reactions; ATP synthesis; regulation of neuromuscular excitability; antiarrhythmic and vasodilatory effects |
4. Applications
| Indication | Use |
|---|---|
| Potassium & Magnesium Deficiency | Hypokalemia and hypomagnesemia of various origins (diuretics, diarrhea, vomiting) |
| Cardiovascular Disease Therapy | Coronary artery disease (angina, myocardial infarction); chronic heart failure; cardiac arrhythmias (especially those caused by K⁺/Mg²⁺ deficiency or cardiac glycosides) |
| Cardiac Glycoside Therapy | Prevention of complications |
| Exercise Tolerance | Improvement of physical performance |
5. Conclusion
Potassium magnesium aspartate is an important preparation for correcting electrolyte imbalances and supporting cardiovascular system function. Its use helps normalize potassium and magnesium levels in the body, improve metabolic processes in the myocardium, and reduce the risk of arrhythmias. The drug is well tolerated and widely used in cardiology practice.
