Phenibut (Aminophenylbutyric Acid) | Anxiolytic | Nootropic

Product Name: Phenibut (β-Phenyl-γ-aminobutyric acid)
Molecular Formula: C₁₀H₁₃NO₂
Structure: Four-carbon chain with an amino group at the γ-position and a phenyl ring at the β-carbon
Appearance: White crystalline powder
Melting Point: 198–200 °C
Solubility: 4–5 g/L in water at 20 °C; freely soluble in alcohols
Stability: Stable when stored in a dry, dark place

1. Introduction

Phenibut (β-phenyl-γ-aminobutyric acid) is a GABA derivative with a phenyl ring addition. It possesses anxiolytic, nootropic, and sedative effects, improving cognitive function and reducing anxiety levels.

The addition of a phenyl fragment to the GABA molecule increases blood-brain barrier penetration and enhances interaction with GABA_B receptors. Phenibut is used for anxiety-depressive disorders, asthenic conditions, and cognitive enhancement.

2. Synthesis

Condensation of phenylacetaldehyde with GABA nitrile (Strecker reaction), followed by hydrolysis and enantiomer separation.

3. Properties

• Appearance: White crystalline powder

• Melting Point: 198–200 °C

• Solubility: 4–5 g/L in water at 20 °C; freely soluble in alcohols

• Stability: Stable when stored in a dry, dark place

4. Applications

• Therapy of anxiety and panic disorders – daily doses 250–750 mg

• Nootropic and psychostimulating complexes

• Comprehensive therapy of asthenic conditions and post-stress syndromes

5. Conclusion

Phenibut is an effective agent for reducing anxiety and improving cognitive function. Long-term use requires gradual withdrawal to avoid discontinuation syndrome.