Lactoferrin (LF) | Iron-Binding Glycoprotein | Immune Support

Product Name: Lactoferrin (LF)
Molecular Weight: Approximately 80,000 Da
Structure: Two-domain protein with two Fe³⁺ binding sites, rich in glycan branches
Appearance: White to cream-colored powder
Solubility: Freely soluble in water at pH 5–7
Stability: Sensitive to proteases and extreme pH; store at 2–8 °C

1. Introduction

Lactoferrin is an iron-binding glycoprotein (≈80 kDa) found in breast milk and saliva. It possesses antimicrobial, immunomodulatory, and anti-inflammatory activity, prevents pathogen adhesion and growth, regulates iron absorption, and reduces oxidative stress.

Lactoferrin is present in colostrum and mucosal secretions, providing newborns with protection against infections and participating in immune system maturation. It is used in pediatrics, gastroenterology, and dentistry for dysbiosis correction and mucosal protection.

2. Production

Obtained from milk using ion exchange and affinity chromatography, followed by lyophilization.

3. Properties

• Appearance: White to cream-colored powder

• Solubility: Freely soluble in water at pH 5–7

• Stability: Sensitive to proteases and extreme pH; store at 2–8 °C

4. Applications

• Pediatrics: Supplements for immune support in infants

• Pharmaceuticals: Sprays and gels for the oral cavity (gingivitis, stomatitis)

• Nutraceuticals: Dysbiosis prevention, iron metabolism support

5. Conclusion

Lactoferrin is a key component of innate immunity and a regulator of iron metabolism. Microencapsulated and lotion forms for mucosal and intestinal protection, as well as complexes with probiotics, are promising.