Curcumin | CAS 458-37-7 | Turmeric Extract

Product Name: Curcumin
CAS No.: 458-37-7
Molecular Formula: C₂₁H₂₀O₆
Structure: Diphenolic dienone (diketone) with conjugated system (HO–Ph–CH=CH–CO–CH=CH–Ph–OH)
Appearance: Orange-yellow crystals or powder
Solubility: Practically insoluble in water; freely soluble in ethanol and DMSO
Melting Point: Approximately 183 °C
Stability: Photosensitive; degrades under alkaline pH and heat

1. Introduction

Curcumin is the primary bioactive component of turmeric root (Curcuma longa). It possesses pronounced antioxidant, anti-inflammatory, and antiproliferative activity, modulating NF-κB, COX-2, and various signaling pathways, making it promising for health support and cancer prevention.

Curcumin has long been used in Ayurvedic and traditional Chinese medicine. Modern research confirms its broad pharmacological spectrum, from protecting cells from oxidative stress to inhibiting tumor cell growth and modulating immune response.

2. Synthesis

Obtained by extraction from turmeric (alcohols, oils) or chemical synthesis from vanillin and acetone (Claisen-Schmidt condensation).

3. Properties

• Appearance: Orange-yellow crystals or powder

• Solubility: Practically insoluble in water; freely soluble in ethanol and DMSO

• Melting Point: Approximately 183 °C

• Stability: Photosensitive; degrades under alkaline pH and heat

4. Applications

• Nutraceuticals: Capsules and tablets for anti-inflammatory and antioxidant effects

• Pharmaceuticals: Adjunctive component in the therapy of gastritis, arthritis, and cancer

• Cosmetics: Anti-aging and regenerative serums

5. Conclusion

Curcumin is a promising natural polyphenol with proven biological effects. Limitations are related to low bioavailability. Research on liposomal, nanodisperse, and phospholipid forms is relevant to improve efficacy.