Hyaluronic Acid | HA | CAS 9004-61-9 | Hydration

Product Name: Hyaluronic Acid (HA)
CAS No.: 9004-61-9
Structural Unit: [−β(1→4)-D-GlcA-β(1→3)-D-GlcNAc−]ₙ
Molecular Weight: 50 kDa to 6 MDa (depends on application)
Appearance: White to yellowish powder or viscous clear gel
Solubility: Fully soluble in water, forming a viscous hydrophilic phase
Viscoelasticity: High viscosity even at low concentrations (0.1–1%)

1. Introduction

Hyaluronic acid is a linear glycosaminoglycan composed of repeating disaccharide units of D-glucuronic acid and N-acetylglucosamine. It uniquely retains up to 1000× its weight in water, forming viscoelastic gels.

In human tissues, hyaluronan is present in the extracellular matrix of skin, cartilage, and synovial fluid. In medicine and cosmetics, it is used for skin hydration, synovial fluid replacement in arthrosis, and as fillers in contouring.

2. Sources and Production

• Sources: Extraction from rooster combs or bacterial fermentation (Streptococcus zooepidemicus)

• Purification: Ultrafiltration and ion exchange to remove proteins and endotoxins

3. Properties

• Appearance: White to yellowish powder or viscous clear gel

• Molecular Weight: 50 kDa to 6 MDa (depends on application)

• Solubility: Fully soluble in water, forming a viscous hydrophilic phase

• Viscoelasticity: High viscosity even at low concentrations (0.1–1%)

4. Applications

• Dermal injections (fillers) – wrinkle and volume correction

• Ophthalmology – moisturizing drops and optical gels

• Orthopedics – intra-articular injections for osteoarthritis

• Cosmetics – serums and masks for deep hydration

5. Conclusion

Hyaluronic acid is a versatile biopolymer for medicine and aesthetics, providing pronounced moisturizing and structuring effects with high biocompatibility.