Gaboxadol Hydrochloride (THIP) | CAS 85118-33-8 | ≥99%

Product Name: Gaboxadol Hydrochloride (GABAA)
CAS No.: 85118-33-8
MF: C₆H₉ClN₂O₂
MW: 176.60
EINECS: 285-687-7
Purity: ≥99.0%
Appearance: White solid

Description

Gaboxadol (also known as THIP) is a direct GABA-mimetic ligand selective for delta-containing GABAA receptors.

Clinical Research History

Gaboxadol has undergone human clinical trials to test its sleep-promoting effects. The drug was generally well tolerated and was shown to enhance delta power during non-REM (NREM) sleep in humans. However, Gaboxadol failed Phase III sleep studies. Side effects were described as moderate and qualitatively similar to those of other GABA-mimetics.

Current Development

Gaboxadol is being developed in partnership with Ovid Therapeutics for the treatment of:

• Angelman syndrome

• Fragile X syndrome

• Epilepsy