Enclomifene | CAS 15690-57-0 | SERM | Testosterone

Product Name: Enclomifene (Enclomiphene)
CAS No.: 15690-57-0
Appearance: Light to cream-colored powder
Solubility: Low water solubility; pronounced lipophilicity, affecting absorption and distribution
Stability: Stable under proper storage conditions

1. Introduction

Enclomifene is the active stereoisomer of clomiphene, acting as a selective estrogen receptor modulator (SERM). It stimulates testosterone production and is used for hormonal balance correction, hypogonadism treatment, and certain forms of male infertility.

Enclomifene belongs to the class of selective estrogen receptor modulators (SERMs) and is used to eliminate the negative feedback of estrogens, leading to increased gonadotropin release and stimulation of testosterone secretion. This agent is relevant for reproductive dysfunction in men.

2. Chemical Structure & Synthesis

Enclomifene is one of the stereoisomers of clomiphene, a triphenylethylene derivative. Its synthesis is carried out through multi-step aromatic substitution reactions and formation of the E-isomer, which has predominant pharmacological activity.

3. Properties

• Appearance: Light to cream-colored powder

• Solubility: Low water solubility; pronounced lipophilicity, affecting absorption and distribution

• Structural stereochemistry: Plays a significant role in its biological activity

4. Applications

Used for the treatment of male hypogonadism, stimulation of endogenous testosterone production, and correction of hypothalamic-pituitary-gonadal axis disorders, helping to improve reproductive function and overall hormonal balance.

5. Conclusion

Enclomifene is an effective agent for hormonal imbalance correction, helping to increase testosterone levels and improve fertility. Further research will help optimize dosages and expand the scope of therapeutic applications.