Diosmin | Flavonoid | CAS 520-27-4 | Venotonic

Product Name: Diosmin
CAS No.: 520-27-4
Molecular Formula: C₂₈H₃₂O₁₅
Appearance: Light yellow to cream-colored powder
Solubility: Sparingly soluble in water; soluble in alcohols and other organic solvents
Stability: Resistant to oxidative processes, ensuring long shelf life
Bioavailability: Improved with specialized drug delivery systems

1. Introduction

Diosmin is a flavonoid glycoside widely used in medicine for its venotonic, vasodilating, and anti-inflammatory properties. It is used to correct symptoms of chronic venous insufficiency, varicose veins, and hemorrhoids. Diosmin strengthens capillary walls and improves microcirculation, positively affecting tissue metabolism.

Chronic venous insufficiency and associated hemorrhagic disorders require agents that help normalize venous tone and improve microcirculation. Diosmin, as a natural component obtained primarily from citrus plants, demonstrates high efficacy in correcting these pathological conditions. It is used both in pharmaceutical preparations and as part of functional food supplements.

2. Chemical Structure & Synthesis

Diosmin is a complex molecular compound belonging to the flavonoid glycoside class. Its structure includes an aglycone (diosmetin) and a sugar residue attached via a glycosidic bond.

Industrial production of diosmin often involves obtaining the glycoside from hesperidin followed by molecular modification to improve bioavailability and stability.

3. Properties

• Appearance: Light yellow to cream-colored powder

• Solubility: Sparingly soluble in water; soluble in alcohols and other organic solvents

• Stability: Resistant to oxidative processes, ensuring long shelf life

• Bioavailability: Improved with specialized drug delivery systems

4. Applications

• Pharmacology: Treatment of chronic venous insufficiency, varicose veins, and hemorrhoid symptoms

• Dietetics: Component of dietary supplements for normalizing blood circulation and metabolism

• Prophylaxis: Strengthening vessel walls and improving microcirculation

5. Conclusion

Diosmin is an effective natural agent that helps normalize venous tone, reduce capillary permeability, and improve microcirculation. Its use in medicine and dietetics confirms its high clinical significance in the treatment and prevention of venous system diseases.