Chondroitin Sulfate | CAS 9007-28-7 | Joint Health

Product Name: Chondroitin Sulfate
CAS No.: 9007-28-7
Repeating Disaccharide Unit: [−β(1→4)-D-GlcA-β(1→3)-D-GalNAc(4,6-OSO₃)]ₙ
Molecular Weight: 10–50 kDa (depends on degree of polymerization)
Appearance: White to slightly yellowish hygroscopic powder
Solubility: Freely soluble in water, forming a viscous solution; insoluble in organic solvents
Ionic Character: Polyvalent anion due to carboxyl and sulfate groups

1. Introduction

Chondroitin sulfate is a sulfated glycosaminoglycan containing repeating disaccharide units of D-glucuronic acid and N-acetyl-D-galactosamine. It is widely used in osteoarthritis therapy and for maintaining joint cartilage health.

Chondroitin sulfate is a component of the extracellular matrix of cartilage tissue, providing elasticity and resistance to compression. In degenerative joint diseases, its endogenous production decreases, leading to cartilage destruction and inflammation.

2. Sources and Production

• Sources: Extraction from bovine or shark cartilage tissue

• Purification: Proteolytic hydrolysis, precipitation with zinc chloride, and multiple dialysis steps

3. Properties

• Appearance: White to slightly yellowish hygroscopic powder

• Molecular Weight: 10–50 kDa (depends on degree of polymerization)

• Solubility: Freely soluble in water, forming a viscous solution; insoluble in organic solvents

• Ionic Character: Polyvalent anion due to carboxyl and sulfate groups

4. Applications

• Oral and injectable preparations for osteoarthritis – daily dose 800–1200 mg

• Nutraceuticals – joint function support

• Cosmetology – masks and serums for improving skin elasticity

5. Conclusion

Chondroitin sulfate is an effective component for protecting and restoring cartilage tissue, possessing chondroprotective and anti-inflammatory effects.