Acetylglutathione | N-Acetylated Glutathione | CAS 3054-47-5

Product Name: Acetylglutathione (N-Acetylglutathione)
CAS No.: 3054-47-5
Molecular Formula: C₁₁H₁₈N₃O₆S
Structure: Glutathione with an acetyl group on the α-amino group of glutamate (Ac–γ(Glu–Cys–Gly))
Appearance: White crystalline powder
Solubility: Freely soluble in water
Stability: Sensitive to high pH and proteases; store at 2–8 °C in dry form

1. Introduction

Acetylglutathione is an N-acetylated tripeptide (γ-glutamyl-cysteinyl-glycine). It possesses antioxidant, detoxification, and cytoprotective effects, penetrates cells better than reduced glutathione, and participates in the regeneration of other antioxidants.

Glutathione is a key intracellular antioxidant, but its direct oral bioavailability is limited. N-terminal acetylation increases stability, resistance to degradation, and cellular absorption. This peptide is being studied as an effective nutraceutical and pharmaceutical ingredient for supporting redox balance.

2. Synthesis

Obtained by acetylation of reduced glutathione with acetic anhydride or acetyl chloride in alkaline medium, followed by purification.

3. Properties

• Appearance: White crystalline powder

• Solubility: Freely soluble in water

• Stability: Sensitive to high pH and proteases; store at 2–8 °C in dry form

4. Applications

• Nutraceuticals: Supplements for detoxification support and antioxidant protection

• Pharmaceuticals: Adjunctive agents for oxidative stress and hepatoprotection

• Cosmetics: Anti-aging and detox serums

5. Conclusion

Acetylglutathione combines a powerful antioxidant profile with improved bioavailability compared to regular glutathione. Research on optimizing dosages and delivery forms for maximum cellular effect is promising.