5-HTP (5-Hydroxytryptophan) | CAS 56-69-9 | Serotonin Precursor

Product Name: 5-HTP (5-Hydroxytryptophan)
CAS No.: 56-69-9
Molecular Formula: C₁₁H₁₂N₂O₃
Structure: Indole ring with hydroxyl group at position 5 and an amino acid "tail"
Appearance: White crystalline powder
Solubility: Moderately soluble in water; freely soluble in dilute acids
Stability: Sensitive to oxidation and moisture; store in sealed containers

1. Introduction

5-HTP (5-Hydroxytryptophan) is an intermediate in serotonin synthesis produced from L-tryptophan. Oral intake increases CNS serotonin levels, improves mood, promotes sleep, and reduces appetite. It is used as a supplement for depression, sleep disorders, and migraines.

5-Hydroxytryptophan is synthesized by Griffonia simplicifolia seeds or chemically from L-tryptophan. It easily crosses the blood-brain barrier and is converted to serotonin. Scientific interest is determined by its potential in the therapy of depression, sleep disorders, fibromyalgia, and migraine.

2. Synthesis

• Natural: Extraction from Griffonia simplicifolia seeds

• Chemical: From L-tryptophan via hydroxylation by tryptophan-5-hydroxylase

3. Properties

• Appearance: White crystalline powder

• Solubility: Moderately soluble in water; freely soluble in dilute acids

• Stability: Sensitive to oxidation and moisture; store in sealed containers

4. Applications

• Nutraceuticals: Serotonin deficiency correction, antidepressant support

• Sleep medicine: Improving sleep quality, regulating sleep-wake cycles

• Neurology: Prevention and reduction of migraine frequency

5. Conclusion

5-HTP is an effective serotonin precursor with proven effects on mood and sleep. Dosage control is required due to the risk of serotonin syndrome when combined with antidepressants. Promising in comprehensive CNS support regimens.