5-Amino-1-methylquinolinium iodide | CAS 42464-96-0 | ≥98%

Product Name: 5-Amino-1-methylquinolin-1-ium iodide
CAS No.: 42464-96-0
Other Names: 5-Amino-1MQ; NNMTi; 5-Amino-1-methylquinolinium iodide
Appearance: Yellow to pink powder
Purity (HPLC): ≥98.0%
Storage Conditions: Keep in a dark, dry, sealed place at 2–8 °C (refrigerated)
Available Documentation: COA, HPLC, HNMR, MS

Description

5-Amino-1-methylquinolinium iodide is an organic salt (CAS 42464-96-0) with an iodide ion. Due to its cationic backbone and amino group in the aromatic ring, this compound is in demand for the production of fluorescent labels, biosensors, and the development of new pharmaceutical drugs.

Biological Activity

5-Amino-1MQ is a small, selective, membrane-permeable molecule that acts as an inhibitor of nicotinamide N-methyltransferase (NNMT). It is a methylquinolinium (MQ) derivative that has demonstrated high efficacy in NNMT inhibition, cell viability, and membrane permeability.

Potential Research Applications

This NNMT inhibitor may be studied for:

• Prevention of adipogenesis and type II diabetes

• Reversal of diet-induced obesity (via increased intracellular NAD⁺ and SAM)

• Activation of stem cells and improvement of skeletal muscle regenerative capacity

Mechanism of Action

The NNMT enzyme is associated with both obesity and type 2 diabetes and plays a role in intracellular energy homeostasis. Inhibition of NNMT has been shown to lead to significant weight loss, reduced fat mass and adipocyte size, and decreased plasma cholesterol and glucose levels.

Animal Study Data

A mouse study administering 5-Amino-1MQ showed a 7% reduction in body weight without any changes in food intake compared to the control group. Research indicates that NNMT reduction may help reduce fat cells and adipose tissue.

⚠️ FOR RESEARCH USE ONLY

This product is intended solely for research purposes as a research chemical. This designation allows the use of research chemicals exclusively for in vitro testing and laboratory experiments. Not for human consumption. No medical or therapeutic claims are made.