2,4-Pyridinedicarboxylic Acid | CAS 499-80-9 | 99%
Histone lysine-specific demethylase inhibitor. Targets JMJD2A (KDM4A), KDM4C, KDM4E (IC50 1.4 µM), KDM5B (IC50 3 µM), KDM6A, and other 2-oxoglutarate-dependent dioxygenases.
Product Name: 2,4-Pyridinedicarboxylic acid (2,4-PDCA)
CAS No.: 499-80-9
EC No.: 207-892-2
Molecular Formula: C₇H₅NO₄
Molecular Weight: 167.12
Purity: 99%
Application
2,4-Pyridinedicarboxylic acid is an inhibitor of histone lysine-specific demethylases targeting:
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JMJD2A (KDM4A) – IC50 1.4 µM
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KDM4C
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KDM4E – IC50 1.4 µM
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KDM5B – IC50 3 µM
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KDM6A
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Other 2-oxoglutarate-dependent dioxygenases
Histone lysine-specific demethylases JMJD2A (KDM4A) and KDM4C are members of the Jumonji domain 2 (JMJD2) family. They function as trimethylation-specific demethylases, converting specific trimethylated histone residues to their dimethylated form. KDM5B is an H3K4me3/me2-specific lysine demethylase.
Packaging
20 kg or 25 kg per drum
