Vitamin K1 Oxide (2,3-Epoxyphytomenadione) CAS 25486-55-9

Vitamin K1 Oxide (2,3-Epoxyphytomenadione) – Stable Derivative for Food and Nutritional Applications

Basic Information

• CAS Number: 25486-55-9

• Chemical Name: 2,3-Epoxy-2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione (2,3-epoxyphylloquinone)

• Synonyms: 2,3-Epoxyphylloquinone, (2,3-epoxyphityl)menaquinone

• Molecular Formula: C₃₁H₄₆O₃

• Molecular Weight: 466.70 g/mol

• Appearance: Pale yellow to golden clear oily liquid, odorless or nearly odorless

• Solubility: Freely soluble in chloroform, ether, and vegetable oils; slightly soluble in ethanol; insoluble in water

• Stability: Sensitive to light; decomposes on exposure; more stable than Vitamin K1 in the same solvent and under light.

Overview
Vitamin K1 2,3-epoxide (also known as 2,3-epoxyphytomenadione) is a naturally occurring derivative of Vitamin K1 (phylloquinone). It is a fat-soluble vitamin produced by plants and serves as an intermediate in the vitamin K cycle. This epoxide form exhibits enhanced stability compared to the parent Vitamin K1, particularly under light exposure and in various solvents, making it a valuable ingredient for food fortification and nutritional supplements.

Applications

• Food additive: Used as a source of vitamin K activity in fortified foods, infant formulas, and dietary supplements.

• Nutritional supplements: Incorporated into oil-based formulations (softgels, capsules) and multi-vitamin products.

• Research: Utilized in biochemical studies of vitamin K metabolism and blood clotting mechanisms.

• Feed additives: Added to animal nutrition products as a source of vitamin K.

Key Benefits

• Greater stability than Vitamin K1 – resistant to photodegradation.

• Fat-soluble – ideal for oil-based formulations.

• Safe and approved for use as a food additive.

• Maintains biological activity comparable to Vitamin K1.

Recommended Use
Typical usage levels: 0.1–1.0% in oil-based formulations, depending on desired vitamin K activity. Follow local regulations for maximum permitted levels in food and supplements.

Handling and Storage

• Store at room temperature in a tightly sealed container, protected from light.

• Avoid prolonged exposure to light and heat to prevent decomposition.

• Use appropriate personal protective equipment (gloves, safety goggles) when handling.

• In case of contact with skin or eyes, rinse thoroughly with water.

Additional Information
We also offer Vitamin K1 (CAS 84-80-0) in liquid and microencapsulated powder forms. Custom formulations are available upon request.

Packaging
Available in 1 kg, 5 kg, 10 kg, and 25 kg containers (drums, bottles). Custom packaging upon request.

Quality Assurance
Each batch is tested for purity (by HPLC), heavy metals, and residual solvents to ensure compliance with food and pharmaceutical standards.