L-Pyroglutamic Acid (PCA) CAS 98-79-3

L-Pyroglutamic Acid (PCA) – Versatile Amino Acid Derivative for Food, Cosmetics, and Pharmaceuticals

Basic Information

• CAS Number: 98-79-3

• Synonyms: 5-Oxoproline, Pidolic acid, PCA, 5-Oxo-L-proline

• Molecular Formula: C₅H₇NO₃

• Molecular Weight: 129.11 g/mol

• Appearance: White crystalline powder

• Melting Point: 162–163°C

• Solubility: Soluble in water, alcohol, acetone, and glacial acetic acid; slightly soluble in ethyl acetate; insoluble in ether

• Packaging: 25 kg per fiber drum with double-layer polyethylene lining (or custom packaging)

Overview
L-Pyroglutamic acid (PCA) is a naturally occurring cyclic derivative of the amino acid glutamine, formed by intramolecular cyclization with the loss of ammonia. It is a key component of the glutamatergic system and plays a role in various biological processes. Though related to glutamine, PCA is structurally and functionally more similar to proline (hence its alternative name, 5-oxoproline). It is found in foods such as meat and eggs, but dietary intake is often insufficient to meet physiological demands, making supplementation and industrial synthesis important.

Biological Role
PCA is involved in the glutathione cycle (gamma-glutamyl cycle) and serves as a carrier for amino acids across cell membranes. It also functions as a neurotransmitter modulator and may support cognitive function by influencing the glutamatergic system.

Applications

• Organic synthesis: Used as a chiral building block and intermediate in the preparation of pharmaceuticals, agrochemicals, and fine chemicals.

• Food industry: Employed as a flavor enhancer, nutritional supplement, and component of functional foods.

• Pharmaceuticals: Used in drug formulations and as an active ingredient in cognitive support and neuroprotective preparations.

• Cosmetics: Added to skin care products for its moisturizing, anti-aging, and skin-conditioning properties, often included in natural moisturizing factor (NMF) blends.

• Nutritional supplements: Available as a dietary supplement for cognitive enhancement and overall wellness.

Key Benefits

• Natural and biocompatible.

• Multifunctional – used in food, pharma, and cosmetics.

• Soluble in water and common solvents for easy formulation.

• Stable under recommended storage conditions.

• Supports cognitive function and skin hydration.

Handling and Storage

• Store in a cool, dry, well-ventilated area, away from direct sunlight and moisture.

• Keep containers tightly sealed to prevent contamination and caking.

• Use appropriate personal protective equipment (gloves, safety goggles, dust mask) when handling.

• Avoid inhalation of dust and contact with skin and eyes.

Quality Assurance
Each batch is tested for purity (by HPLC), melting point, and heavy metal content to ensure compliance with food, pharmaceutical, and cosmetic standards.