L-Citrulline CAS 372-75-8

L-Citrulline – Key Amino Acid for Nitric Oxide Production and Ammonia Detoxification

Basic Information

• CAS Number: 372-75-8

• Molecular Formula: C₆H₁₃N₃O₃

• Molecular Weight: 175.19 g/mol

• Synonyms: (S)-2-Amino-5-ureidopentanoic acid

• Appearance: White crystalline powder

• Solubility: Freely soluble in water; poorly soluble in organic solvents

• Melting Point: 214–218°C

Overview
L-Citrulline is a naturally occurring non-essential amino acid that plays a central role in the urea cycle, helping to detoxify ammonia and regulate nitrogen balance in the body. Unlike many amino acids, L-citrulline is not incorporated into proteins but serves as a key intermediate in the synthesis of L-arginine and nitric oxide (NO). This makes it a valuable compound for cardiovascular health, athletic performance, and metabolic regulation. Its unique metabolic pathway allows it to bypass first-pass metabolism and provide a sustained source of arginine and NO.

Biochemical Role
L-Citrulline is produced in the intestine from glutamine and is also generated during the urea cycle in the liver. It is converted to L-arginine in the kidneys and endothelial cells, where it serves as a substrate for nitric oxide synthase (NOS). This process enhances NO production, leading to vasodilation, improved blood flow, and better oxygen and nutrient delivery to tissues. Additionally, L-citrulline supports the urea cycle by facilitating ammonia removal, preventing toxic accumulation in the body.

Key Benefits

• Supports nitric oxide production – promotes vasodilation and blood flow.

• Enhances ammonia detoxification – protects against ammonia buildup during exercise.

• Improves athletic performance – reduces fatigue, supports recovery, and improves endurance.

• Supports cardiovascular health – helps maintain healthy blood pressure and endothelial function.

• Increases arginine bioavailability – more effectively raises arginine levels than arginine supplementation alone.

Applications

• Sports nutrition: Used in pre-workout and recovery formulations to reduce muscle fatigue and improve performance.

• Cardiovascular health: Supplemented to support healthy blood pressure, endothelial function, and circulation.

• Metabolic support: Beneficial for conditions involving ammonia toxicity and urea cycle disorders.

• Anti-aging and wellness: Investigated for its antioxidant and immune-supporting properties.

Safety and Storage

• L-citrulline is generally recognized as safe (GRAS) when used as a dietary supplement.

• Store in a cool, dry place, away from moisture and direct sunlight.

• Keep containers tightly sealed to prevent contamination.

• Use appropriate personal protective equipment (gloves, dust mask) when handling.

Packaging
Available in 1 kg, 5 kg, 10 kg, and 25 kg containers. Custom packaging upon request.

Quality Assurance
Each batch is tested for purity (by HPLC), heavy metals, and microbial contamination to ensure compliance with food and supplement standards.