Hydrafinil (9-Fluorenol) | Nootropic | CAS 1689-64-1

Product Name: Hydrafinil (9-Fluorenol)
CAS No.: 1689-64-1
Molecular Formula: C₁₃H₁₀O
Structure: Fluorene with a hydroxyl group at position 9 (9H-fluoren-9-ol)
Appearance: White to off-white crystals
Melting Point: Approximately 154 °C
Solubility: Practically insoluble in water (<0.1 g/L); soluble in ethanol, acetone, and DMSO
Stability: Stable when stored in a dry, dark place

1. Introduction

Hydrafinil (9-Fluorenol) is a nootropic and stimulant agent structurally related to modafinil. It possesses mild wakefulness-promoting effects, improves cognitive function, and increases resistance to fatigue without pronounced euphoric effects.

Hydrafinil first gained attention as an alternative to modafinil. Compared to modafinil, it demonstrates a milder increase in alertness and cognitive activity with less impact on blood pressure and sleep.

2. Synthesis

Typically synthesized by reduction of fluorenone (9-fluorenone) with hydrogen in the presence of a nickel catalyst:

• Starting compound: 9-Fluorenone

• Reagents: H₂/Pt–Ni or hydrazine/KOH

• Product: 9-Fluorenol (Hydrafinil)

3. Properties

• Appearance: White to off-white crystals

• Melting Point: Approximately 154 °C

• Solubility: Practically insoluble in water (<0.1 g/L); soluble in ethanol, acetone, and DMSO

• Stability: Stable when stored in a dry, dark place

4. Applications

• Nootropics and mental performance: Improved attention and memory during mental tasks

• Wakefulness promotion: Alternative agent for shift-work sleep disorders

• Sports: Short-term enhancement of endurance

5. Conclusion

Hydrafinil is a promising wakefulness-promoting stimulant with low toxicity and mild nootropic effects. Clinical studies are needed to assess long-term safety and optimize dosing.