Phytosphingosine CAS 554-62-1

Phytosphingosine – Bioactive Phospholipid with Anticancer Properties

Basic Information

• Product Name: Phytosphingosine

• Product Code: GKT220033

• CAS Number: 554-62-1

• Molecular Formula: C₁₈H₃₉NO₃

• EINECS Number: 205-516-1

• Appearance: White powder

• Packaging: 1 kg per bag.

Overview
Phytosphingosine is a naturally occurring long‑chain base phospholipid, a type of sphingolipid that is structurally similar to sphingosine but with an additional hydroxyl group at the C4 position. It is found in various organisms and is known for its significant biological activities, particularly its anticancer effects.

Biological Properties

• Anticancer activity: Phytosphingosine induces programmed cell death (apoptosis) in cancer cells through a well‑defined mechanism involving activation of caspase‑8 and translocation of the pro‑apoptotic protein Bax to the mitochondria. This pathway triggers the intrinsic and extrinsic apoptotic cascades, leading to cell death in various cancer cell lines.

• Other bioactivities: It also exhibits antimicrobial, anti‑inflammatory, and skin barrier‑enhancing properties, making it valuable in dermatological and cosmetic applications.

Applications

• Cancer research: Used as a tool compound to study apoptosis and cancer biology; potential therapeutic agent for certain cancers.

• Cosmetics and personal care: Incorporated into skin care formulations for its moisturizing, anti‑aging, and antimicrobial effects, helping to restore skin barrier function.

• Pharmaceutical research: Investigated as a lead compound for drug development targeting apoptotic pathways.

• Biochemical studies: Used in sphingolipid metabolism research and as a standard in lipid analysis.

Recommended Use
For research applications, typical concentrations range from 1 to 50 µM in cell culture studies, depending on cell type and experimental objectives. In cosmetic formulations, usage levels are generally 0.1–1% by weight.

Handling and Storage

• Store in a cool, dry place, protected from light and moisture.

• Keep containers tightly sealed to prevent degradation.

• Use standard laboratory precautions when handling; avoid inhalation and skin contact.

Quality Assurance
Each batch is tested for purity (HPLC), identity, and moisture content to ensure high quality and reproducibility.