Phenyl Acetate CAS 122-79-2

Phenyl Acetate – Aromatic Ester for Perfumery, Flavorings, and Pharmaceutical Synthesis

Basic Information

• CAS Number: 122-79-2

• Molecular Formula: C₈H₈O₂

• Molecular Weight: 136.15 g/mol

• Synonyms: Phenyl acetate, Acetic acid phenyl ester

• Appearance: Clear, colorless to pale yellow liquid

• Odor: Pleasant, fruity-floral aroma

• Boiling Point: 196–198°C

• Density: ~1.08 g/cm³ at 20°C

• Solubility: Slightly soluble in water; miscible with alcohol, ether, and most organic solvents

Chemical Properties
Phenyl acetate is an ester formed from phenylacetic acid and an alcohol (typically ethanol or other alcohols). It features a benzyl (phenyl) moiety linked to an acetate group. The molecule is stable under normal storage conditions but undergoes hydrolysis in alkaline media, yielding phenylacetic acid and the corresponding alcohol. It is a colorless liquid with a distinct, pleasant, sweet-floral odor.

Synthesis

• Classical esterification: Reaction of phenylacetic acid with ethanol (or other alcohols) in the presence of an acid catalyst (e.g., sulfuric acid).

• Transesterification: Exchange of ester groups between phenylacetic acid and other esters under appropriate conditions.

Applications

• Perfumery and flavors: Widely used as a fragrance ingredient in perfumes, soaps, and cosmetics, imparting fruity and floral notes. Also employed as a flavoring agent in food products.

• Pharmaceutical intermediates: Serves as a key intermediate in the synthesis of various drugs, including some non-steroidal anti‑inflammatory agents and other active pharmaceutical ingredients.

• Chemical synthesis: Used as a reagent and building block in the preparation of other organic compounds.

Safety and Handling

• Phenyl acetate is generally considered low in toxicity but may cause mild irritation upon contact with skin or eyes.

• Use appropriate personal protective equipment (gloves, safety goggles) when handling.

• In case of spillage, absorb with inert material and dispose of according to local regulations.

• Keep away from strong oxidizers and alkalis, as hydrolysis may occur.

Environmental Aspects
Phenyl acetate is readily biodegradable under aerobic conditions. However, large spills may pose a risk to aquatic life; prompt containment and cleanup are advised.

Storage

• Store in a cool, dry, well‑ventilated area, away from direct sunlight and heat.

• Keep containers tightly sealed to prevent evaporation and contamination.

• Shelf life: typically 24 months under recommended conditions.

Packaging
Available in 1 L, 5 L, 25 L, and 200 L drums, as well as custom packaging upon request.

Quality Assurance
Each batch is tested for purity (by GC), color, acid value, and water content to ensure consistent quality.