p-Hydroxyacetophenone CAS 99-93-4

p-Hydroxyacetophenone (4-Hydroxyacetophenone) – Versatile Intermediate for Pharmaceuticals and Flavors

Basic Information

• CAS Number: 99-93-4

• Molecular Formula: C₈H₈O₂

• Molecular Weight: 136.15 g/mol

• Synonyms: 4-Hydroxyacetophenone, 4-Acetylphenol, p-Acetylphenol

• Appearance: White to off-white crystalline powder

• Melting Point: 109–111°C

• Boiling Point: 313°C

• Solubility: Soluble in ethanol, ether, and hot water; slightly soluble in cold water

Overview
p-Hydroxyacetophenone is a para-substituted phenolic compound with both ketone and hydroxyl functionality. Its unique structure makes it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, fragrances, and polymers. It is also known for its potent antioxidant activity, which contributes to its utility in both chemical and biological applications.

Applications

• Pharmaceutical synthesis: Key intermediate in the production of analgesic drugs (e.g., paracetamol analogs), antibacterial agents, and other bioactive compounds.

• Flavor and fragrance industry: Used as a precursor for the synthesis of aroma chemicals and flavoring agents.

• Polymer chemistry: Acts as a chain terminator, stabilizer, or monomer in specialty polymers.

• Antioxidant additive: Exhibits free radical scavenging properties, making it useful in food, cosmetic, and polymer stabilization.

• Research: Used as a standard and reagent in organic chemistry and biochemistry.

Key Properties

• Good thermal stability.

• Exhibits mild acidity (phenolic hydroxyl).

• Readily undergoes electrophilic substitution and carbonyl reactions.

• Non-toxic at recommended handling levels (but standard precautions apply).

Handling and Storage

• Store in a cool, dry, well-ventilated area, away from direct sunlight and strong oxidizers.

• Keep containers tightly sealed to prevent moisture absorption and contamination.

• Use appropriate personal protective equipment (gloves, safety goggles, dust mask) when handling.

• Avoid inhalation of dust and contact with skin and eyes.

Packaging
Available in 1 kg, 5 kg, 25 kg, and 50 kg containers (fibre drums, polyethylene bags). Custom packaging upon request.

Quality Assurance
Each batch is tested for purity (by HPLC), melting point, and moisture content to ensure consistent quality.