Octyl Cyanoacrylate CAS 6701-17-3

N-Octyl Cyanoacrylate – Monomer for Surgical Adhesives and Hemostatic Applications

Basic Information

• Chemical Name: 2-Propanoic acid, 2-cyano-, octyl ester (Octyl 2-cyanoacrylate)

• CAS Number: 6701-17-3

• EINECS Number: 229-748-8

• Molecular Formula: C₁₂H₁₉NO₂

• Appearance: Clear, colorless to pale yellow liquid

• Polymerization: Rapidly polymerizes upon contact with water, moisture, and anionic surfaces, forming strong bonds.

Overview
N-Octyl cyanoacrylate (often referred to as octyl cyanoacrylate) is a monomer specifically designed for medical adhesive applications. It is the key ingredient in surgical tissue adhesives used for wound closure, hemostasis, and as an alternative to traditional sutures and staples. The compound rapidly polymerizes in the presence of moisture, forming a strong, flexible bond with tissue. Its biocompatibility and low toxicity make it suitable for internal and external medical use.

Applications

• Surgical adhesives: Used as a primary component in tissue glues for closing incisions and lacerations.

• Hemostatic agents: Applied to control bleeding in surgical and emergency settings by creating a physical barrier and promoting clotting.

• Wound closure: Provides a waterproof, flexible seal that reduces the risk of infection and minimizes scarring.

• Medical devices: Used for fixation of catheters and other implantable devices.

• Veterinary medicine: Employed in similar applications for animal surgery.

Mechanism of Action
Octyl cyanoacrylate undergoes anionic polymerization initiated by contact with water or hydroxyl ions present on tissue surfaces. The reaction is rapid and exothermic but well‑tolerated. The polymerized film adheres strongly to tissue, providing mechanical support and sealing the wound.

Key Properties

• Fast curing – sets within seconds to minutes.

• High bond strength – provides durable tissue adhesion.

• Biocompatible – meets medical grade requirements.

• Low toxicity – suitable for internal applications.

• Flexible film – accommodates tissue movement without cracking.

• Hydrophobic – provides a moisture barrier.

Handling and Storage

• Store in a cool, dry place, away from moisture and heat.

• Keep containers tightly sealed to prevent premature polymerization.

• Use in well‑ventilated areas; avoid contact with skin and eyes.

• Store at recommended temperature (typically 2–8°C) to extend shelf life.

Packaging
Available in 1 mL, 5 mL, 10 mL, and bulk quantities, depending on application. Custom packaging upon request.

Quality Assurance
Each batch is tested for purity (GC), water content, and polymerization time to ensure consistent performance.