Dimethyl Furan-2,5-dicarboxylate – Organic and Pharmaceutical Intermediate
Basic Information
English Name: Dimethyl furan-2,5-dicarboxylate
Synonyms: Dimethyl 2,5-furandicarboxylate; 2,5-Furandicarboxylic acid dimethyl ester
CAS Number: 4282-32-0
Molecular Formula: C₈H₈O₅
Molecular Weight: 184.15 g/mol
Density: 1.244 g/cm³
Boiling Point: 270.9°C at 760 mmHg
Flash Point: 117.6°C
Refractive Index: 1.48
Overview
Dimethyl furan-2,5-dicarboxylate is a versatile ester derived from furandicarboxylic acid. It serves as a valuable intermediate in organic synthesis and pharmaceutical development. Its structure contains a furan ring with two ester groups, making it a useful building block for the preparation of polymers, biologically active compounds, and specialty chemicals.
Applications
Organic synthesis: Used as an intermediate in the preparation of various functionalized compounds, including heterocycles and substituted furans.
Pharmaceutical research: Serves as a precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
Chemical production: Employed in laboratory R&D and small‑scale manufacturing processes.
Materials science: Investigated as a renewable building block for biobased polymers and resins.
Key Properties
High purity grade suitable for research and development.
Stable under normal storage conditions.
Soluble in organic solvents (e.g., ethanol, ether, dichloromethane).
Reactive ester groups allow for further derivatization.
Handling and Storage
Store in a cool, dry, well‑ventilated area, away from oxidizers and moisture.
Keep containers tightly sealed to prevent hydrolysis and contamination.
Use standard laboratory precautions when handling (gloves, safety goggles, fume hood).
Avoid inhalation and skin contact.
Packaging
Available in various laboratory pack sizes (e.g., 5 g, 25 g, 100 g, 500 g, 1 kg) and custom packaging upon request.
Quality Assurance
Each batch is analyzed for purity (by GC or HPLC), moisture content, and physical properties to ensure consistent quality.