Chlorphenesin CAS 104-29-0

Chlorphenesin – Muscle Relaxant and Cosmetic Preservative

Basic Information

• CAS Number: 104-29-0

• Molecular Formula: C₉H₁₁ClO₃

• Molecular Weight: 202.63 g/mol

• Synonyms: 3-(p-Chlorophenoxy)-1,2-propanediol; Chlorphenesin carbamate

• Appearance: White to off-white crystalline powder

• Solubility: Slightly soluble in water; soluble in ethanol, propylene glycol, and other organic solvents

Overview
Chlorphenesin is a chlorophenol derivative with dual functionality: it acts as a muscle relaxant in pharmaceutical applications and as a broad‑spectrum preservative in cosmetic and personal care products. Its antimicrobial activity is effective against a wide range of bacteria, fungi, and yeasts, making it a valuable ingredient in formulations requiring preservation.

Applications

• Pharmaceuticals: Used as a centrally acting muscle relaxant to relieve skeletal muscle spasms and tension.

• Cosmetics and personal care: Employed as a preservative in creams, lotions, shampoos, conditioners, and other water‑based formulations to prevent microbial contamination.

• Other uses: Occasionally found in topical preparations and as an antimicrobial agent in certain industrial products.

Mechanism of Action

• Muscle relaxant: Acts on the central nervous system to reduce muscle tone and spasticity.

• Preservative: Disrupts microbial cell membranes and inhibits enzyme systems, preventing the growth of bacteria and fungi.

Key Benefits

• Effective at low concentrations (0.1–0.5% in cosmetic applications).

• Broad‑spectrum antimicrobial activity.

• Good compatibility with many cosmetic ingredients and surfactants.

• Stable across a wide pH range.

Precautions and Safety

• May cause skin irritation or sensitization in some individuals; patch testing recommended for leave‑on products.

• Use concentrations should be carefully controlled to avoid irritation and ensure safety.

• Not for internal use; for external applications only.

• Requires monitoring of dosage in pharmaceutical applications to avoid adverse effects.

Handling and Storage

• Store in a cool, dry, well‑ventilated area, away from direct sunlight and moisture.

• Keep containers tightly sealed to prevent contamination.

• Use appropriate personal protective equipment (gloves, safety goggles, dust mask) when handling.

• Avoid inhalation of dust and contact with skin and eyes.

Packaging
Available in 1 kg, 5 kg, 25 kg containers, and custom packaging upon request.

Quality Assurance
Each batch is tested for purity (by HPLC), melting point, and heavy metal content to ensure consistent quality.