Cetylpyridinium Chloride Monohydrate CAS 6004-24-6

Cetylpyridinium Chloride Monohydrate – High-Purity Antimicrobial for Oral Care and Preservation

Basic Information

• Product Name: Cetylpyridinium chloride monohydrate

• Product Code: GKL-22006

• CAS Number: 6004-24-6

• Molecular Formula: C₂₁H₄₀ClNO

• Purity: ≥99%

• Appearance: White crystalline powder

• Solubility: Soluble in water, ethanol, and propylene glycol; sparingly soluble in organic solvents.

Overview
Cetylpyridinium chloride monohydrate (CPC) is a cationic quaternary ammonium compound with broad-spectrum antimicrobial activity. It is widely used in oral care and personal care products due to its ability to kill bacteria and other microorganisms. It is effective against Gram‑positive and Gram‑negative bacteria, fungi, and some viruses.

Mechanism of Action
CPC disrupts bacterial cell membranes through electrostatic interaction with negatively charged membrane components, leading to leakage of cellular contents and cell death. It also reduces surface tension, aiding in plaque disruption.

Applications

• Oral care products: Used in mouthwashes, toothpastes, throat sprays, and gargles to reduce plaque formation, prevent gingivitis (gum inflammation), and control halitosis.

• Preservative: Acts as a preservative in personal care formulations, ophthalmic solutions, and topical preparations due to its antimicrobial efficacy.

• Cosmetics: Incorporated in skin cleansers, shampoos, and deodorants for antimicrobial protection.

• Pharmaceuticals: Used in topical disinfectants and antiseptic formulations.

• Veterinary: Applied in animal health products.

Recommended Usage
In oral care formulations, typical concentrations are 0.05–0.1% by weight. For preservation, use levels of 0.1–0.5% depending on the product and challenge microorganisms.

Key Benefits

• High purity (≥99%) ensures consistent performance and safety.

• Effective at low concentrations.

• Good compatibility with nonionic and amphoteric surfactants; avoid anionic surfactants that can form insoluble complexes.

• Stable over a wide pH range (4–8).

• Does not stain teeth or alter taste significantly at recommended levels.

Handling and Storage

• Store in a cool, dry place, protected from light and moisture.

• Keep containers tightly sealed to prevent caking and contamination.

• Use appropriate personal protective equipment (gloves, safety goggles, dust mask) when handling.

• Avoid contact with strong oxidizers and anionic surfactants.

Packaging
Available in 25 g, 100 g, 500 g, 1 kg, and 25 kg containers. Custom packaging upon request.

Quality Assurance
Each batch is analyzed for purity (by HPLC or titration), water content (Karl Fischer), and microbial quality to ensure product performance and regulatory compliance.