2,4-Dichlorobenzyl Alcohol (DCBA) CAS 1777-82-8

2,4-Dichlorobenzyl Alcohol (DCBA) – Antiseptic for Throat Lozenges and Sprays

Basic Information

• CAS Number: 1777-82-8

• Molecular Formula: C₇H₆Cl₂O

• Molecular Weight: 177.03 g/mol

• Appearance: White to off-white crystalline powder

• Melting Point: 57–60°C

• Solubility: Slightly soluble in water; soluble in ethanol, propylene glycol, and organic solvents

Overview
2,4-Dichlorobenzyl alcohol (DCBA) is a halogenated aromatic alcohol with well-established antiseptic properties. It is widely used as an active ingredient in over‑the‑counter throat lozenges, oral sprays, and mouthwashes for the symptomatic relief of sore throat and oral infections. Its dual action against bacteria and fungi makes it a valuable component in topical antimicrobial formulations.

Mechanism of Action
DCBA exerts its antimicrobial effect by disrupting microbial cell membranes and denaturing proteins, leading to cell death. It is particularly effective against gram‑positive bacteria and certain fungi, including Candida species. Its anti‑inflammatory properties help reduce throat irritation and swelling.

Applications

• Throat lozenges and sprays: Used as an active antiseptic for sore throat relief, often combined with other active ingredients (e.g., benzocaine, menthol) for enhanced efficacy.

• Oral care: Incorporated into mouthwashes and gargles for oral hygiene and infection prevention.

• Topical antiseptics: Used in creams and ointments for minor skin infections and wounds.

• Pharmaceuticals: As an antimicrobial agent in various medicinal preparations.

Key Benefits

• Effective against a broad spectrum of gram‑positive bacteria and fungi.

• Low systemic toxicity when used topically or orally at recommended doses.

• Provides symptomatic relief by reducing throat inflammation.

• Stable and easy to formulate into solid and liquid dosage forms.

• Well‑tolerated with minimal side effects.

Recommended Use
Typically used at concentrations of 0.5–2% in throat lozenges and sprays. Follow local regulatory guidelines and product-specific formulations.

Handling and Storage

• Store in a cool, dry, well‑ventilated area, away from direct sunlight and moisture.

• Keep containers tightly sealed to prevent contamination.

• Use appropriate personal protective equipment (gloves, safety goggles, dust mask) when handling.

• Avoid inhalation of dust and contact with skin and eyes.

Packaging
Available in 1 kg, 5 kg, 25 kg containers, and custom packaging upon request.

Quality Assurance
Each batch is tested for purity (by HPLC), melting point, and heavy metal content to ensure consistent quality for pharmaceutical applications.