Thiamidol (Isobutylamido Thiazolyl Resorcinol)

Thiamidol (Isobutylamido Thiazolyl Resorcinol) – Advanced Tyrosinase Inhibitor for Skin Brightening

Basic Information

• Product Name: Isobutylamido thiazolyl resorcinol

• Other Name: Thiamidol

• CAS Number: 1428450-95-6

• Appearance: White to off-white powder

• Purity: ≥98% (HPLC)

• Odor: Characteristic

• Particle Size: 100% passing 80 mesh

• Solubility: Soluble in glycols (propylene glycol, butylene glycol); insoluble in water

• Storage: 24 months at room temperature, protected from light and heat

Overview
Thiamidol (isobutylamido thiazolyl resorcinol) is an advanced resorcinol derivative specifically designed to inhibit tyrosinase activity and melanin production at its source. Unlike conventional brightening agents, Thiamidol directly interferes with melanogenesis, reducing both melanin synthesis and its transfer to keratinocytes. With proven efficacy at concentrations as low as 0.2%, it offers a highly effective solution for hyperpigmentation, age spots, melasma, and uneven skin tone.

Key Mechanisms of Action

1. Tyrosinase inhibition: Directly inhibits the activity of tyrosinase, the key enzyme in melanin synthesis.

2. Melanin transfer inhibition: Prevents the transport of melanosomes from melanocytes to keratinocytes, reducing visible pigmentation.

3. Targeted action: Specifically designed to block melanogenesis without interfering with other skin processes.

Advantages Over Other Resorcinol Derivatives

• Stability: Overcomes the instability issues of 4‑butylresorcinol and 4‑hexylresorcinol (which have low melting points and tend to discolor).

• Reduced irritation: Minimizes the risk of skin irritation and side effects often associated with other resorcinol derivatives when used at effective concentrations.

• Flexible formulation: Does not restrict addition levels as significantly as 4‑phenethylresorcinol, allowing broader formulation possibilities.

Applications

• Skin brightening: Reduces melanin production and evens out skin tone.

• Hyperpigmentation treatment: Effective for dark spots, melasma, age spots, and post‑inflammatory hyperpigmentation.

• Anti‑aging: Combines brightening benefits with antioxidant properties for a more radiant complexion.

• All skin types: Suitable for sensitive skin when used at recommended concentrations.

Recommended Use

• Typical concentration: 0.1–0.5% of the formulation.

• Standard brightening products: 0.1–0.2%

• Spot correctors and intensive treatments: 0.3–0.5% (higher concentrations may cause skin irritation)

• Formulation guidelines: Solubilize in glycols (propylene glycol, butylene glycol) at temperatures not exceeding 80°C for a short period. Avoid direct water addition. Add to the main formula after solubilization.

Safety and Handling

• Store in a cool, dry place, protected from light, heat, and moisture.

• Handle with appropriate personal protective equipment (gloves, safety goggles) when working with the raw material.

• Avoid skin contact during handling; use in well‑ventilated areas.

• Conduct patch tests before incorporating into final products.

• Shelf life: 24 months under recommended storage conditions.

Packaging
Available in 1 kg, 5 kg, 10 kg, and 25 kg containers (bags, drums, or boxes). Custom packaging upon request.

Quality Assurance
Each batch is tested for purity (by HPLC), particle size, and heavy metal content to ensure consistent quality.