Guaiazulene CAS 489-84-9

Guaiazulene – Anti-Inflammatory and Antioxidant Active for Skin Care

Basic Information

• Product Name: Guaiazulene (Guaiazulenum)

• CAS Number: 489-84-9

• Molecular Formula: C₁₅H₁₈

• Molecular Weight: 198.30 g/mol

• EINECS Number: 207-701-2

• Appearance: Dark blue crystals, liquid, or powder

• Purity (GC): ≥99.5%

• Packaging: 1 kg per aluminum bottle

Overview
Guaiazulene is a naturally occurring azulene derivative known for its potent anti-inflammatory and antioxidant properties. It is widely used in dermatological and cosmetic formulations to soothe irritated skin, reduce redness and swelling associated with acne, and protect the skin from oxidative stress caused by free radicals. Its deep blue color is characteristic and imparts a distinctive appearance to finished products. Guaiazulene is also valued in sunscreens for its additional protective benefits.

Mechanism of Action
Guaiazulene exerts its anti-inflammatory effect by inhibiting the release of pro-inflammatory mediators, helping to calm skin irritation and reduce erythema. Its antioxidant activity neutralizes free radicals, preventing premature skin aging and damage. These dual actions make it effective in treating acne-prone skin and in formulations aimed at soothing sensitive or inflamed skin.

Applications

• Acne treatments: Helps reduce redness, swelling, and inflammation associated with acne breakouts.

• Anti-aging products: Provides antioxidant protection to minimize free radical damage.

• Sunscreens: Adds an extra layer of skin protection against UV-induced oxidative stress.

• Soothing creams and lotions: Used in products for sensitive, irritated, or inflamed skin conditions.

• Cosmetics: Imparts a natural blue color and calming properties to various skincare and makeup products.

Recommended Use
Typical usage levels in cosmetic formulations range from 0.01% to 0.5%, depending on the desired efficacy and color intensity. Guaiazulene is generally well-tolerated and safe for topical application at recommended concentrations.

Handling and Storage

• Store in a cool, dry place, protected from light and moisture.

• Keep containers tightly sealed to prevent oxidation and degradation.

• Use appropriate personal protective equipment (gloves, safety goggles) when handling.

• Shelf life: typically 24 months under recommended storage conditions.

Quality Assurance
Each batch is tested for purity (by GC), appearance, and stability to ensure consistent quality.