Dimethyl Isosorbide (DMI) CAS 5306-85-4

Dimethyl Isosorbide (DMI) – Versatile Solvent for Pharmaceuticals, Cosmetics, and Agrochemicals

Basic Information

• Product Name: Dimethyl Isosorbide

• CAS Number: 5306-85-4

• Molecular Formula: C₈H₁₄O₄

• Molecular Weight: 174.19 g/mol

• Appearance: Colorless transparent liquid

• Solubility: Freely miscible with water; soluble in ether, ethanol, and other polyols

• Operating Range: Wide temperature range from –50°C to >200°C

• Safety Profile: Non-irritating, non-toxic, very safe for topical and transdermal applications

Overview
Dimethyl isosorbide (DMI) is a high-purity, versatile solvent derived from renewable sorbitol. It is widely used in the pharmaceutical, cosmetic, and agrochemical industries due to its excellent solubility profile, wide temperature range, and outstanding safety characteristics. DMI is a clear, colorless, odorless liquid that is completely miscible with water and most organic solvents, making it an ideal carrier for active ingredients in various formulations.

Key Properties

• Excellent solubilizing power – dissolves both hydrophilic and lipophilic compounds.

• Complete miscibility with water, alcohols, ethers, and polyols.

• Extremely broad operating temperature range (–50°C to >200°C).

• Non-toxic, non-irritating, and safe for skin contact.

• Biodegradable and environmentally friendly.

• Enhances transdermal and topical penetration of active ingredients.

Applications

• Cosmetics: Used in sunscreens, anti-aging products, moisturizers, skin protection, and slimming/weight-loss formulations as a solubilizer and penetration enhancer.

• Pharmaceuticals: Employed as a solvent in ointments, tinctures, and transdermal drug delivery systems to improve bioavailability.

• Agrochemicals: Enhances the penetration of pesticides into insect bodies, reduces pest resistance, lowers application rates, and minimizes environmental contamination.

• Other uses: As a solvent and carrier in specialty chemical formulations and industrial applications.

Recommended Use
Typical usage levels depend on the application:

• Cosmetics: 1–30% by weight.

• Pharmaceuticals: as needed for solubility and bioavailability.

• Agrochemicals: formulated to achieve optimal penetration and efficacy.

• Compatibility testing recommended for specific formulations.

Handling and Storage

• Store in a cool, dry, well-ventilated area, away from direct sunlight and moisture.

• Keep containers tightly sealed to prevent evaporation and contamination.

• Use appropriate personal protective equipment (gloves, safety goggles) when handling.

• Shelf life: typically 24 months under recommended storage conditions.

Packaging
Available in 200 kg drums (PTFE-lined) or custom packaging upon request.

Quality Assurance
Each batch is tested for purity, water content, and physical properties to ensure consistent quality.