Phenylethyl Resorcinol CAS 85-27-8

Phenylethyl Resorcinol – Advanced Tyrosinase Inhibitor for Skin Brightening and Pigmentation Correction

Basic Information

• CAS Number: 85-27-8

• Molecular Formula: C₁₄H₁₄O₂

• Molecular Weight: 214.26 g/mol

• Synonyms: 4-(1-Phenylethyl)resorcinol, Phenylethyl resorcinol

• Appearance: White to off‑white crystalline powder

• Melting Point: 78–82°C

• Solubility: Limited solubility in water; soluble in ethanol, propylene glycol, and glycols

• Storage: Store in tightly sealed containers at room temperature, protected from light and moisture

Overview
Phenylethyl resorcinol is a synthetic organic compound belonging to the resorcinol family. Its structure features a resorcinol ring (1,3‑dihydroxybenzene) with a phenylethyl side chain at the para position, which enhances its lipophilicity and skin penetration. This compound is widely recognized as a potent tyrosinase inhibitor, making it a valuable active ingredient in cosmetic formulations aimed at skin brightening, pigmentation correction, and even skin tone improvement.

Mechanism of Action
Phenylethyl resorcinol inhibits tyrosinase, the key enzyme responsible for melanin biosynthesis. By blocking the conversion of tyrosine to DOPA and subsequent melanin formation, it reduces melanin production in melanocytes. This results in lighter skin pigmentation, fading of age spots, sun spots, and post‑acne marks. Additionally, its antioxidant properties help protect skin cells from oxidative stress, further contributing to a brighter and more even complexion.

Key Benefits

• Potent tyrosinase inhibition – effectively reduces melanin production.

• Improves skin tone and reduces hyperpigmentation.

• Helps fade post‑inflammatory hyperpigmentation (post‑acne marks).

• Stable at moderate temperatures and compatible with various cosmetic formulations.

• Suitable for sensitive skin when used at recommended concentrations.

• Non‑irritating at typical use levels (0.1–1.0%).

Applications

• Cosmetics and skincare: Used in brightening serums, creams, emulsions, and spot correctors for age spots, melasma, and sun damage.

• Anti‑aging products: Often combined with antioxidants and peptides to address pigmentation associated with photoaging.

• Dermatological treatments: Included in products for post‑acne pigmentation and uneven skin tone.

• Research: Studied for its effects on melanogenesis and oxidative stress pathways.

Recommended Use
Typical concentration: 0.1–1.0% in cosmetic formulations. For best results, combine with other brightening agents (e.g., niacinamide, vitamin C, licorice extract) and sun protection. Incorporate into the oil phase or solubilize in glycols prior to emulsification.

Handling and Storage

• Store in a cool, dry place, protected from light, heat, and moisture.

• Keep containers tightly sealed to prevent oxidation and degradation.

• Use appropriate personal protective equipment (gloves, safety goggles) when handling.

• Shelf life: typically 24 months under recommended conditions.

Quality Assurance
Each batch is tested for purity (by HPLC), melting point, and heavy metal content to ensure consistent quality.