N-Acetyl Semax (AC-SEMAX) Neuropeptide 98%

N-Acetyl Semax – Synthetic Heptapeptide for Neurobiological and Cognitive Research

Basic Information

• Product Name: N-Acetyl Semax (AC-SEMAX)

• CAS Number: 2920938-90-3 

• Molecular Formula: C₃₉H₅₄N₁₀O₁₀S 

• Molecular Weight: 854.97 g/mol 

• Sequence (One‑Letter Code): {Ac}‑MEHFPGP‑NH₂ 

• Sequence (Three‑Letter Code): Ac‑Met‑Glu‑His‑Phe‑Pro‑Gly‑Pro‑NH₂ 

• Appearance: White to off‑white lyophilized powder 

• Purity: ≥98% (HPLC) 

• Solubility: Soluble in sterile water or bacteriostatic water 

• Storage: Powder at –20°C (up to 3 years); solution at –20°C (up to 6 months) 

Overview
N‑Acetyl Semax is a synthetic heptapeptide derivative of the well‑studied neuropeptide Semax, which itself is a fragment of adrenocorticotropic hormone (ACTH) encompassing the sequence 4–10 . Belonging to the melanocortin family, this modified peptide features an N‑terminal acetylation and a C‑terminal amidation, which confer enhanced metabolic stability and resistance to enzymatic degradation compared to the unmodified parent peptide .

Key Properties

• Enhanced stability: Acetylation and amidation increase resistance to proteolytic cleavage, extending the peptide's half‑life in biological systems .

• Blood‑brain barrier penetration: Capable of crossing the blood‑brain barrier, making it valuable for central nervous system studies .

• Metal ion coordination: Forms stable complexes with Cu²⁺ and Zn²⁺ at physiological pH, which may influence its biological activity .

• Neuroprotective and cognitive effects: Exhibits potential for neuroprotection, cognitive enhancement, and neurogenic effects .

Applications

• Neuropharmacology: Used to probe melanocortin receptor activation and downstream signaling pathways in neural and endocrine systems .

• Cognitive and behavioral research: Employed in in vitro and in vivo models to study learning, memory, and cognitive performance .

• Neuroprotection and synaptic plasticity: Investigated for its influence on neurotrophic factors, oxidative stress responses, and neural cell survival pathways .

• Peptide stability and modification studies: Serves as a model compound for studying the impact of N‑terminal modifications on peptide longevity, metabolic processing, and structural resilience .

• Receptor binding and SAR analysis: Used to elucidate structure‑activity relationships and the structural determinants of peptide‑receptor engagement .

• Assay development and analytical method optimization: Functions as a reference standard for HPLC, mass spectrometry, and peptide quantification protocols .

Handling and Storage

• Store lyophilized powder at –20°C in tightly sealed containers, protected from light and moisture .

• For research use only; not for human therapeutic or diagnostic use .

• Reconstitute in sterile water or bacteriostatic water as required .

• Use appropriate personal protective equipment (gloves, lab coat, safety goggles) when handling.

Packaging
Available in vials (e.g., 1 mg, 5 mg, 10 mg). Custom packaging upon request.

Quality Assurance
Each batch is tested for purity (by HPLC ≥98%), identity (by mass spectrometry), and sequence confirmation to ensure consistent quality.