HGH Fragment 176-191 (AOD-9604) Peptide

HGH Fragment 176-191 (AOD-9604) – Synthetic Peptide for Metabolic Research

Basic Information

• Product Name: HGH Fragment 176-191 (AOD-9604)

• CAS Number: 66004-57-7

• Molecular Formula: C₇₈H₁₂₃N₂₃O₂₂S₂

• Molecular Weight: ~1799.08 g/mol

• Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (disulfide bridge Cys7–Cys14)

• Purity: ≥98% (HPLC)

• Appearance: White lyophilized powder

• Packaging: Available in vials

Overview
HGH Fragment 176-191, also known as AOD-9604, is a synthetic peptide corresponding to amino acids 176–191 of the C‑terminal region of human growth hormone (hGH). This fragment was developed to isolate the lipolytic (fat‑breaking) properties of hGH while eliminating its effects on blood sugar and growth. It is widely used in research on fat metabolism, obesity, and lipid regulation.

Mechanism of Action
HGH Fragment 176-191 stimulates lipolysis (breakdown of fat) and inhibits lipogenesis (conversion of non‑fat materials into body fat) without affecting IGF-1 or GH signaling pathways. It is believed to increase fat oxidation and energy expenditure while promoting the generation of myoblasts.

Applications

• Fat metabolism research: Investigating lipid breakdown, fat oxidation, and inhibition of lipid accumulation in adipocytes.

• Obesity and weight management: Studying potential applications in fat loss and metabolic regulation.

• Metabolic disorders: Exploring the peptide’s role in regulating energy homeostasis and glucose metabolism.

• Muscle and tissue regeneration: Investigating myoblast generation and tissue repair mechanisms.

• Pharmacology: Evaluating the peptide’s effects on insulin release and glucose metabolism.

Key Benefits

• Selective lipolytic activity without growth-promoting or hyperglycemic side effects.

• Stimulates fat breakdown and inhibits fat accumulation.

• Does not stimulate IGF-1 or GH signaling, offering a more targeted research tool.

• Well-characterized synthetic peptide with a defined sequence and high purity.

• Extensively studied in metabolic and obesity research.

Handling and Storage

• Store lyophilized powder at –20°C in tightly sealed containers, protected from light and moisture.

• After reconstitution, store at –80°C and avoid repeated freeze‑thaw cycles.

• Reconstitute in sterile water or suitable buffer as required.

• For research use only; not for human therapeutic or diagnostic use.

• Use appropriate personal protective equipment (gloves, lab coat, safety goggles) when handling.

Quality Assurance
Each batch is tested for purity (by HPLC ≥98%), identity (by mass spectrometry), and sequence confirmation to ensure consistent quality.