HCG 500 (Human Chorionic Gonadotropin)

HCG (Human Chorionic Gonadotropin) – Glycoprotein Hormone for Reproductive and Endocrine Research

Basic Information

• Product Name: HCG (Human Chorionic Gonadotropin)

• CAS Number: 9002-61-3

• Molecular Weight: ~36.7 kDa (dimer)

• Appearance: White lyophilized powder

• Purity: ≥98% (HPLC)

• Packaging: Available in vials (e.g., 500 IU, 1000 IU, 5000 IU)

Overview
Human chorionic gonadotropin (hCG) is a glycoprotein hormone composed of an alpha and beta subunit. It is naturally produced by the placenta during pregnancy and shares structural similarity with luteinizing hormone (LH), allowing it to bind and activate the LH receptor. This property makes hCG a valuable tool in reproductive and endocrine research, where it is used to mimic the LH surge for ovulation induction, support spermatogenesis, and regulate hormone levels.

Mechanism of Action
HCG binds to the LH/hCG receptor on target cells, activating downstream signaling pathways that stimulate steroidogenesis and gametogenesis. In females, it triggers the final maturation of oocytes and ovulation. In males, it stimulates Leydig cells to produce testosterone, supporting spermatogenesis and secondary sexual characteristics.

Applications

• Fertility research: Used to induce ovulation in controlled ovarian hyperstimulation protocols and to support the luteal phase.

• Male reproductive health: Investigated for the treatment of hypogonadism and preservation of spermatogenesis.

• Hormone regulation: Employed in studies on testosterone production and endocrine function.

• Assisted reproductive technology: Used to trigger oocyte maturation in IVF cycles.

• Immunology and diagnostics: Serves as an immunogen for antibody production and as a standard in hormone assays.

Recommended Use
For research use only. Not for human therapeutic or diagnostic use. Dosage and administration should be determined based on specific study protocols. Typical research dosages range from 500 to 5000 IU, depending on the experimental model.

Handling and Storage

• Store lyophilized powder at –20°C in tightly sealed containers, protected from light and moisture.

• After reconstitution, store at –80°C and avoid repeated freeze‑thaw cycles.

• Reconstitute in sterile water or bacteriostatic water as required.

• Use appropriate personal protective equipment (gloves, lab coat, safety goggles) when handling.

Quality Assurance
Each batch is tested for purity (by HPLC ≥98%), identity (by mass spectrometry), and biological activity to ensure consistent quality.