Gonadorelin Acetate (GnRH) Peptide CAS 34973-08-5

Gonadorelin Acetate – Synthetic Decapeptide GnRH Agonist for Reproductive Research

Basic Information

• Product Name: Gonadorelin Acetate (GnRH, Gonadotropin-Releasing Hormone)

• CAS Number: 34973-08-5

• Synonyms: Gonadorelin (INN), ABBOTT-41070, Fertagyl

• Molecular Formula: C₅₇H₇₉N₁₇O₁₅ (acetate salt)

• Molecular Weight: ~1242.36 g/mol

• Appearance: White to off‑white lyophilized powder

• Purity: ≥98% (HPLC)

• Sequence: Synthetic decapeptide identical to native GnRH

• Storage: Store at –20°C, protected from light and moisture

Overview
Gonadorelin acetate is a synthetic decapeptide that is structurally identical to the endogenous gonadotropin‑releasing hormone (GnRH) produced by the hypothalamus. It acts as a specific agonist of the GnRH receptor (GnRHR) and is widely used in research on reproductive endocrinology, fertility, and hormonal regulation.

Mechanism of Action
Gonadorelin binds to GnRH receptors on the anterior pituitary gland, triggering a signaling cascade that stimulates the synthesis and secretion of two key gonadotropins: luteinizing hormone (LH) and follicle‑stimulating hormone (FSH). These hormones are essential for the regulation of reproductive function, including ovulation, spermatogenesis, and steroidogenesis.

Applications

• Reproductive endocrinology research: Investigating the hypothalamic‑pituitary‑gonadal axis, ovulation, and fertility regulation.

• Fertility studies: Used to study ovulation synchronization, as demonstrated in dairy cow models.

• Hormonal disorder research: Exploring conditions such as hypogonadism, polycystic ovary syndrome, and endometriosis.

• Drug development: Serves as a foundational scaffold for GnRH‑based therapeutics.

• Analytical chemistry: Used as a reference standard in method development and quality control.

Key Benefits

• Synthetic peptide identical to natural GnRH, ensuring physiological relevance.

• High potency and selectivity for the GnRH receptor.

• Well‑characterized decapeptide with a defined sequence and high purity.

• Extensive use in both basic research and clinical studies.

• Suitable for in vitro and in vivo experimental models.

Handling and Storage

• Store lyophilized powder at –20°C in tightly sealed containers, protected from light and moisture.

• After reconstitution, store at –80°C and avoid repeated freeze‑thaw cycles.

• For research use only; not for human therapeutic or diagnostic use.

• Use appropriate personal protective equipment (gloves, lab coat, safety goggles) when handling.

Quality Assurance
Each batch is tested for purity (by HPLC ≥98%), identity (by mass spectrometry), and sequence confirmation to ensure consistent quality.