GHRP-2 & GHRP-6 Peptides (Growth Hormone Releasing Peptides)

GHRP-2 and GHRP-6 – Growth Hormone-Releasing Peptides for Endocrine Research

Basic Information

• Product Names: GHRP-2 (Pralmorelin, KP-102, GPA-748); GHRP-6 (Growth Hormone-Releasing Hexapeptide 6)

• CAS Number: 158861-67-7

• Purity: ≥98% (HPLC)

• Appearance: White to off-white lyophilized powder

• Packaging: Available in vials (e.g., 1 mg, 5 mg, 10 mg)

GHRP-2

• Molecular Formula: C₄₅H₅₅N₉O₆

• Molecular Weight: 817.99 g/mol

• Sequence (One‑Letter Code): H‑D‑Ala‑D‑2Nal‑Ala‑Trp‑D‑Phe‑Lys‑NH₂

• Solubility: >12.45 mg/mL in water (with ultrasonic); >74.1 mg/mL in DMSO

• Storage: Store at –20°C

GHRP-6

• Synonyms: GH-releasing hexapeptide, SKF 110679

• Mechanism: Ghrelin receptor agonist

Overview
GHRP-2 (Pralmorelin) and GHRP-6 are synthetic hexapeptide growth hormone secretagogues that act as potent agonists of the ghrelin/growth hormone secretagogue receptor (GHS‑R1a). They stimulate the release of growth hormone (GH) from the anterior pituitary gland. GHRP-2 was developed as a diagnostic agent for growth hormone deficiency and for the treatment of pituitary disorders. Both peptides have been detected in seizure samples from athletes, indicating significant research interest in their GH‑releasing properties.

Mechanism of Action
GHRP-2 and GHRP-6 bind to the ghrelin receptor (GHS‑R1a) on pituitary somatotrophs, activating intracellular signaling pathways that lead to GH secretion. In rat primary pituitary cells, GHRP-2 was found to stimulate GH release via the same receptor and mechanism as GHRP-6, despite structural differences between the peptides.

Applications

• Endocrine research: Studying GH secretion, growth hormone deficiency, and pituitary function.

• Metabolic disorders: Investigating cachexia, obesity, and related conditions.

• Muscle and tissue regeneration: Exploring GH‑mediated anabolic and repair pathways.

• Pharmacology: Evaluating ghrelin receptor agonists and their downstream effects.

• Diagnostic development: GHRP-2 has been tested as a diagnostic aid for GH deficiency in adults.

Recommended Use
For research use only. Not for human therapeutic or diagnostic use. Typical in vitro and in vivo dosages should be determined based on specific study protocols. Reconstitute in sterile water or suitable buffer as required.

Handling and Storage

• Store lyophilized powder at –20°C in tightly sealed containers, protected from light and moisture.

• Once reconstituted, store at –80°C and avoid repeated freeze‑thaw cycles.

• The product is hygroscopic; ensure proper sealing.

• Use appropriate personal protective equipment (gloves, lab coat, safety goggles) when handling.

Quality Assurance
Each batch is tested for purity (by HPLC ≥98%), identity (by mass spectrometry), and sequence confirmation to ensure consistent quality.