Follistatin 344 Peptide (FST344)

Follistatin 344 (FST344) – Myostatin Inhibitor for Muscle and Regenerative Research

Basic Information

• Product Name: Follistatin 344 (FST344, FS344)

• CAS Number: 129954-34-3

• Molecular Formula: C₃₃H₅₇N₁₁O₉

• Molecular Weight: ~751.9 g/mol

• Purity: ≥98% (HPLC)

• Appearance: White lyophilized powder

• Packaging: Available in vials (e.g., 1 mg, 5 mg)

Overview
Follistatin 344 is one of two isoforms of the follistatin protein (the other being FST317), produced by alternative splicing of the precursor mRNA. It is a single‑chain glycoprotein that binds and neutralizes members of the TGF‑β superfamily, including activin and myostatin. By inhibiting these signaling molecules, Follistatin 344 plays a key role in regulating muscle growth, tissue repair, and endocrine function.

Key Properties

• Binds to activin and myostatin with high affinity.

• Promotes muscle hypertrophy and hyperplasia by blocking myostatin signaling.

• Supports tissue regeneration and repair.

• Modulates follicle‑stimulating hormone (FSH) release.

• Well‑characterized isoform with 344 amino acids.

Applications

• Muscle growth research: Investigated for its ability to increase skeletal muscle mass and strength in models of muscular dystrophy and age‑related muscle loss.

• Neuromuscular disorders: Explored in conditions such as Duchenne Muscular Dystrophy, Becker Muscular Dystrophy, and inclusion body myositis.

• Regenerative medicine: Studied for tissue plasticity, organ fibrosis, and wound healing.

• Endocrinology: Used in research on FSH regulation and gonadal function.

• Metabolic signaling: Investigated for its role in metabolic and developmental pathways.

Safety and Handling

• For research use only; not for human therapeutic use.

• Store lyophilized powder at 2–8°C or –20°C for long‑term storage, protected from light and moisture.

• Reconstitute in sterile water or appropriate buffer.

• Use appropriate personal protective equipment (gloves, lab coat, safety goggles) when handling.

Quality Assurance
Each batch is tested for purity (by HPLC), peptide content, and identity (by mass spectrometry) to ensure consistent quality.