Epitalon (Tetrapeptide) 98% Purity

Epitalon – Synthetic Tetrapeptide for Longevity and Cellular Health Research

Basic Information

• Product Name: Epitalon (Epithalon, Epithalone)

• CAS Number: 64082-79-7 (free base); 307297-39-8 (acetate salt)

• Molecular Formula: C₁₄H₂₂N₄O₉

• Molecular Weight: 390.35 g/mol

• Sequence: Ala-Glu-Asp-Gly (AEDG)

• Purity: ≥98% (HPLC)

• Appearance: White to off-white powder

• Packaging: 10 mg per vial

Overview
Epitalon (also known as Epithalon) is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly (AEDG). It was originally designed based on the active component of the bovine pineal gland extract epithalamin. This peptide has been extensively studied for its geroprotective, neuroendocrine, and anti-aging properties.

Mechanism of Action
Epitalon acts primarily through up-regulation of telomerase activity, the enzyme responsible for maintaining telomere length. By increasing telomerase expression, it promotes cellular longevity and genomic stability. Additionally, Epitalon regulates pineal gland function, stimulates melatonin synthesis, and exhibits antioxidant, neuroprotective, and antimutagenic effects. It also modulates immune function and reduces inflammation by regulating cytokines.

Key Benefits

• Supports telomere maintenance and cellular longevity.

• Regulates neuroendocrine and pineal gland function.

• Exhibits antioxidant and neuroprotective properties.

• Modulates immune response and reduces inflammation.

• Potential application in age-related and degenerative conditions.

• Well-studied in experimental gerontology and regenerative medicine.

Applications

• Anti-aging research: Investigated for its ability to extend lifespan and improve healthspan in animal models.

• Neuroprotection: Studied for retinal wound healing, diabetic retinopathy, and neurodegenerative conditions.

• Immunomodulation: Explored for its effects on immune function and inflammatory diseases.

• Cancer research: Exhibits anticancer and anti-tumor metastatic effects.

• Pineal gland regulation: Enhances melatonin synthesis and circadian rhythm regulation.

• Regenerative medicine: Used in studies on stem cell differentiation and tissue repair.

Recommended Dosage
For research purposes only. Typical laboratory dosages range from 5–10 mg per day, administered in 1–2 divided doses. Course duration is typically 10–20 days, with repeat courses recommended after 4–6 months. Always follow specific study protocols.

Handling and Storage

• Store at –20°C in tightly sealed containers, protected from light and moisture.

• For research use only; not for human therapeutic use.

• Use appropriate personal protective equipment (gloves, lab coat, safety goggles) when handling.

• Reconstitute in sterile water, PBS, or DMSO as required.

Packaging
Available in 10 mg vials. Custom packaging upon request.

Quality Assurance
Each batch is tested for purity (by HPLC), peptide content, and identity (by mass spectrometry) to ensure consistent quality.