Dermorphin Peptide 98% Purity

Dermorphin – Natural Heptapeptide μ‑Opioid Receptor Agonist for Pain Research

Basic Information

• Product Name: Dermorphin

• CAS Number: 77614-16-5

• Molecular Formula: C₄₀H₅₀N₈O₁₀

• Molecular Weight: 802.87 g/mol

• Sequence: H‑Tyr‑D‑Ala‑Phe‑Gly‑Tyr‑Pro‑Ser‑NH₂ (YaFGYPS‑NH₂)

• Purity: ≥98% (HPLC)

• Appearance: White powder

• Packaging: 5 mg per vial

Overview
Dermorphin is a naturally occurring heptapeptide originally isolated from the skin of the South American frog Phyllomedusa sauvagei. It belongs to a new class of potent opioid peptides and is distinguished by the presence of a D‑amino acid residue (D‑Ala) in its sequence – a rare feature among peptides synthesized by animal cells. Dermorphin acts as a highly selective and potent agonist of the μ‑opioid receptor (MOR).

Biological Activity

• μ‑Opioid receptor agonist: Binds to MOR with high affinity and selectivity.

• Potent analgesic: Produces long‑lasting analgesia and is significantly more potent than morphine.

• Neuropathic pain inhibition: Used in research models to study neuropathic pain mechanisms.

• Unique structure: The D‑Ala residue is crucial for its bioactivity and has inspired the development of numerous synthetic analogs.

Applications

• Pain research: Studied as a model compound for understanding opioid receptor function and developing novel analgesics.

• Opioid pharmacology: Used to investigate μ‑opioid receptor signaling, tolerance, and dependence.

• Drug development: Serves as a lead structure for designing non‑invasive analgesic peptides.

• Neurobiology: Applied in studies of nociception, catalepsy, and neurotropic activity.

Handling and Storage

• Store lyophilized peptide in a dry form at 0–5°C.

• For long‑term storage, keep at –20°C or below, protected from light and moisture.

• For research use only; not for human therapeutic use.

• Use appropriate personal protective equipment (gloves, lab coat, safety goggles) when handling.

• Reconstitute in sterile water, PBS, or DMSO as required.

Quality Assurance
Each batch is tested for purity (by HPLC), identity (by mass spectrometry), and peptide content to ensure consistent quality.