Bremelanotide (PT-141) Peptide CAS 189691-06-3

Bremelanotide (PT-141) – Synthetic Cyclic Peptide Melanocortin Receptor Agonist

Basic Information

• Product Name: Bremelanotide (PT-141, PT 141)

• CAS Number: 189691-06-3

• Molecular Formula: C₅₀H₆₈N₁₄O₁₀

• Molecular Weight: 1025.16–1025.18 g/mol

• Purity: ≥98% (HPLC)

• Appearance: White to off-white powder

• Sequence: Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys) (cyclic heptapeptide)

• Storage: Store lyophilized at –20°C, protected from light and moisture

Overview
Bremelanotide (formerly PT-141) is a synthetic cyclic heptapeptide analog of α‑melanocyte‑stimulating hormone (α‑MSH). It acts as a melanocortin receptor agonist with potency at MC1R, MC4R, MC3R, MC5R, and MC2R receptors. The compound is brain‑penetrant and activates hypothalamic and limbic regions involved in sexual behavior. Bremelanotide was FDA‑approved in 2019 for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women and is also researched off‑label for male sexual function.

Mechanism of Action
Bremelanotide binds to melanocortin receptors, particularly MC3R and MC4R, which are expressed primarily in the central nervous system. Upon binding, it activates Gαs protein‑coupled signaling, leading to adenylyl cyclase activation and increased intracellular cAMP. Activation of MC4R increases dopamine release, thereby inducing appetitive sexual behaviors. The compound has been studied for pro‑erectile effects and enhanced sexual desire.

Applications

• Research on sexual dysfunction: Investigated for hypoactive sexual desire disorder (HSDD) in women and erectile dysfunction in men.

• Neuropharmacology: Used to study melanocortin receptor signaling, dopamine release, and central nervous system pathways involved in sexual behavior.

• Additional research areas: Explored for hemorrhagic shock and reperfusion injury.

Recommended Use
For research use only. Not for human therapeutic or diagnostic use. Typical in vitro and in vivo dosages should be determined based on specific study protocols. Reconstitute in sterile water or suitable buffer as required.

Handling and Storage

• Store lyophilized peptide at –20°C in tightly sealed containers, protected from light and moisture.

• Avoid repeated freeze‑thaw cycles.

• Use appropriate personal protective equipment (gloves, lab coat, safety goggles) when handling.

Packaging
Available in vials (e.g., 5 mg, 10 mg). Custom packaging upon request.

Quality Assurance
Each batch is tested for purity (by HPLC ≥98%), identity (by mass spectrometry), and peptide content to ensure consistent quality.