AOD-9604 Peptide (Fat Metabolism Research)

AOD-9604 – Synthetic Lipolytic Peptide for Metabolic and Obesity Research

Basic Information

• Product Name: AOD-9604 (Anti-Obesity Drug 9604)

• CAS Number: 221231-10-3

• Synonyms: hGH Fragment 177-191, AOD9604

• Molecular Formula: C₇₈H₁₂₃N₂₃O₂₃S₂

• Molecular Weight: 1815.10 g/mol (free base)

• Sequence: H-Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-OH (disulfide bond)

• Purity: ≥98% (HPLC)

• Appearance: White to off-white lyophilized powder

• Solubility: Slightly soluble in DMSO

• Storage: Store at –20°C

Overview
AOD-9604 is a synthetic peptide derived from the C-terminal fragment (amino acids 177–191) of human growth hormone (hGH), with an additional tyrosine residue at the N-terminus. It was developed as a potential anti-obesity agent that selectively isolates the lipolytic (fat-burning) properties of hGH while eliminating its effects on blood sugar and growth. AOD-9604 is nearly identical to HGH Fragment 176-191, sharing the same amino acid sequence from positions 177 to 191.

Mechanism of Action
AOD-9604 stimulates lipolysis (fat breakdown) and inhibits lipogenesis (fat formation). Research suggests it may activate beta-3 adrenergic receptors in fat cells, leading to enhanced fat oxidation. Importantly, it does not stimulate IGF-1 or GH signaling like full-length growth hormone, making it a more targeted research tool.

Key Research Applications

• Metabolic and obesity research: Studied for its ability to support healthy fat metabolism, encourage fat breakdown, and limit new fat formation. In animal studies, AOD-9604 (250 µg/kg per day) decreased body weight and adipose tissue mass in obese mice.

• Cartilage and joint research: Enhances cartilage regeneration and shows potential in osteoarthritis models.

• Bone metabolism: Modulates the action of osteoblasts and osteoclasts, providing a framework for studying bone formation and resorption.

• Tissue repair and regeneration: Emerging research suggests roles in tissue repair and regenerative medicine.

Recommended Use
For research use only. Not for human therapeutic or diagnostic use. Reconstitute in sterile water or suitable buffer as required. Store lyophilized powder at –20°C, protected from light and moisture.

Quality Assurance
Each batch is tested for purity (by HPLC ≥98%), identity (by mass spectrometry), and sequence confirmation to ensure consistent quality.