Tetraglycerin (Tetraglycerol) CAS 56491-53-3

Tetraglycerin – Oligomeric Polyol for Humectant, Emulsifier, and Polymer Applications

Basic Information

• CAS Number: 56491-53-3

• Molecular Formula: C₁₂H₃₂O₁₂

• Molecular Weight: 320.34 g/mol

• Appearance: Colorless to slightly yellowish viscous liquid or syrup

• Solubility: Highly soluble in water and polar solvents (alcohols, glycols)

• Storage: Store in tightly sealed containers at room temperature, protected from moisture and light

Overview
Tetraglycerin is a glycerol oligomer composed of four glycerol units, retaining all twelve hydroxyl (–OH) groups without loss of water during synthesis. This high density of hydroxyl groups provides exceptional hydrophilicity, hydrogen-bonding capacity, and chemical reactivity. Tetraglycerin is used as a versatile ingredient in cosmetic, pharmaceutical, and polymer applications.

Applications

• Cosmetics and personal care: Acts as a humectant, emulsifier, and skin conditioner in creams, lotions, serums, and hair care products; improves texture, hydration, and emulsion stability.

• Pharmaceuticals: Employed as a drug delivery carrier, stabilizer, and plasticizer in topical formulations and liposomal systems.

• Polymer synthesis: Used as a monomer or branching agent in the production of polyesters, polyurethanes, and other functional polymers.

• Industrial: Applied as a plasticizer, solvent, and component in specialty chemical formulations.

Key Benefits

• Excellent water solubility and humectant properties.

• Mild and non‑irritating – suitable for sensitive skin and biological systems.

• Effective as an emulsifier and stabilizer.

• Stable over a wide temperature range.

• Biocompatible and low toxicity.

• Derived from renewable glycerol sources.

• Compatible with a wide range of ingredients.

Safety and Handling

• Generally recognized as safe (GRAS) for use in food and cosmetics.

• Low irritation potential; well‑tolerated by skin and mucous membranes.

• Avoid contact with strong oxidizers and acids.

• Store in a cool, dry place, away from direct sunlight.

• Use appropriate personal protective equipment (gloves, safety goggles) when handling.

Quality Assurance
Each batch is tested for purity, water content, and functional properties to ensure consistent quality.