Pyridoxamine Dihydrochloride (PADC) CAS 524-36-7

Pyridoxamine Dihydrochloride (PADC) – Vitamin B6 Derivative with Antioxidant and Anti-Glycation Properties

Basic Information

• CAS Number: 524-36-7

• Molecular Formula: C₈H₁₂N₂O₂·2HCl

• Molecular Weight: 241.11 g/mol

• Synonyms: Pyridoxamine 2HCl, 4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol dihydrochloride

• Appearance: White to off-white crystalline powder

• Solubility: Highly soluble in water; slightly soluble in ethanol

• Storage: Store in a cool, dry place, protected from light and moisture

Overview
Pyridoxamine dihydrochloride (PADC) is a stable, water-soluble form of pyridoxamine, one of the active forms of vitamin B₆. Unlike other B6 vitamers, pyridoxamine exhibits unique antioxidant and anti-glycation properties, making it a valuable ingredient in pharmaceutical, cosmetic, and nutraceutical applications. It is particularly effective at inhibiting the formation of advanced glycation end-products (AGEs), which are implicated in aging, diabetes complications, and neurodegenerative disorders.

Mechanism of Action

• AGE inhibition: Pyridoxamine traps reactive carbonyl intermediates (e.g., glyoxal, methylglyoxal) that form during glycation, preventing the formation of AGEs.

• Antioxidant activity: Scavenges free radicals and chelates metal ions, reducing oxidative stress.

• Cell protection: Protects proteins and lipids from oxidative damage, preserving cellular function.

• Enzyme cofactor: Serves as a coenzyme for various enzymatic reactions involved in amino acid metabolism.

Applications

• Pharmaceuticals: Used in research and formulations targeting diabetes complications, cardiovascular health, and neurodegenerative diseases (e.g., Alzheimer's, diabetic neuropathy).

• Cosmetics: Incorporated into anti-aging serums, creams, and lotions to reduce oxidative stress, improve skin texture, and prevent glycation-induced skin aging.

• Nutraceuticals: Added to dietary supplements for antioxidant support and metabolic health.

• Other: Used in biochemical research and as a reference standard in analytical chemistry.

Key Benefits

• Powerful inhibitor of AGE formation – slows glycation-related aging processes.

• Strong antioxidant activity – protects cells from oxidative damage.

• Water-soluble – easy to formulate in aqueous systems.

• Stable and safe – well-tolerated with low irritation potential.

• Compatible with a wide range of pharmaceutical and cosmetic ingredients.

• Suitable for oral, topical, and injectable applications.

Recommended Use
Typical usage levels depend on the application:

• Pharmaceuticals: As directed by clinical protocols (often 50–300 mg per day).

• Cosmetics: 0.5–2.0% in anti-aging formulations.

• Nutraceuticals: 10–100 mg per serving.

• For optimal performance, dissolve in the water phase with moderate heating (40–60°C).

Safety and Handling

• Generally recognized as safe at recommended concentrations.

• Low irritation potential; well-tolerated by skin.

• Avoid contact with strong oxidizers and acids.

• Store in a cool, dry place, away from direct sunlight and moisture.

• Use appropriate personal protective equipment (gloves, safety goggles) when handling.

• Shelf life: typically 24 months under recommended storage conditions.

Quality Assurance
Each batch is tested for purity (by HPLC), moisture content, and heavy metals to ensure consistent quality and compliance with pharmaceutical and cosmetic standards.