Octisalate (Ethylhexyl Salicylate) UV Filter CAS 118-60-5

Octisalate (Ethylhexyl Salicylate) – Lipophilic UVB Filter for Sunscreen and Cosmetic Formulations

Basic Information

• CAS Number: 118-60-5

• Molecular Formula: C₁₅H₂₂O₃

• Molecular Weight: 250.33 g/mol

• Synonyms: Ethylhexyl salicylate, 2-Ethylhexyl salicylate, Octisalate

• Appearance: Colorless to pale yellow liquid

• Density: ~1.02 g/cm³ at 20°C

• Boiling Point: ~169°C (at reduced pressure)

• Solubility: Insoluble in water; miscible with ethanol, isopropanol, and cosmetic oils

• Storage: Store in a cool, dry place at temperatures up to 25°C, protected from light and air

Overview
Octisalate (ethylhexyl salicylate) is an organic UV filter belonging to the salicylate ester family. It efficiently absorbs UVB radiation (280–320 nm) and provides moderate protection against UVA. Its lipophilic nature allows it to form a uniform film on the skin, enhancing the water resistance of sunscreen formulations. Octisalate is widely used in sunscreens, day creams, and other cosmetic products to improve UV protection and overall product texture.

Mechanism of Action
Octisalate absorbs UVB radiation through its aromatic ring system, dissipating the energy as heat. It does not penetrate deeply into the skin, making it a safe and effective UV filter for topical use. When combined with other UV filters (e.g., avobenzone, octocrylene), it helps stabilize the formulation and extends the spectrum of protection.

Applications

• Sunscreens: Used as a primary UVB filter in sunscreens, moisturizers, and tinted products.

• Water-resistant formulations: Enhances film formation, reducing wash-off and improving water resistance.

• Stabilizer: Helps stabilize more photolabile UV filters (e.g., avobenzone) against degradation.

• Cosmetics: Provides a smooth, non-greasy feel, improving the sensory properties of creams, lotions, and sprays.

• Other uses: Occasionally used in lip balms, foundations, and after-sun products for added UV protection.

Key Benefits

• Effective UVB absorption.

• Improves water resistance and longevity of sunscreen products.

• Enhances spreadability and provides a pleasant, non-greasy feel.

• Compatible with a wide range of oils and organic solvents.

• Safe and well-tolerated at recommended concentrations (2–5%).

• Stabilizes other UV filters, extending overall protection.

Safety and Handling

• Generally recognized as safe at concentrations up to 5% in sunscreens.

• May cause mild irritation in sensitive individuals; patch testing recommended.

• Store in a cool, dry place, away from direct sunlight and heat.

• Use appropriate personal protective equipment (gloves, safety goggles) when handling.

• Shelf life: typically 24 months under recommended storage conditions.

Quality Assurance
Each batch is tested for purity (by HPLC), color, and UV absorption characteristics to ensure consistent performance.