Isopropyl Myristate CAS 110-27-0

Isopropyl Myristate – Emollient and Penetration Enhancer for Cosmetics and Pharmaceuticals

Basic Information

• CAS Number: 110-27-0

• Molecular Formula: C₁₇H₃₄O₂

• Molecular Weight: 270.45 g/mol

• Synonyms: Isopropyl myristate, IPM

• Appearance: Clear, colorless to slightly yellowish liquid

• Odor: Practically odorless

• Density: ~0.85 g/cm³ (at 20°C)

• Boiling Point: ~208°C (at reduced pressure, ~5 mmHg)

• Flash Point: 110–120°C

• Solubility: Practically insoluble in water; soluble in alcohols, ethers, and oils

• Storage: Store in tightly sealed containers at 5–30°C, protected from light

Overview
Isopropyl myristate is the ester of isopropyl alcohol and myristic acid, widely used in cosmetic and pharmaceutical formulations. Its light, non-greasy texture and excellent spreading properties make it a popular emollient in skin care products. It is also known as a penetration enhancer, improving the absorption of active ingredients through the stratum corneum. Unlike many other esters, isopropyl myristate is non-comedogenic, making it suitable for products designed for acne-prone or sensitive skin.

Applications

• Cosmetics and personal care: Used in creams, lotions, sunscreens, makeup removers, and hair care products.

• Pharmaceuticals: Acts as a penetration enhancer in topical formulations and transdermal delivery systems.

• Color cosmetics: Improves pigment dispersion and spreadability in foundations, lipsticks, and other makeup products.

• Industrial: Used as a lubricant, plasticizer, and solvent in various formulations.

Key Benefits

• Provides a light, non-greasy skin feel.

• Enhances spreadability and absorption of active ingredients.

• Non-comedogenic – does not clog pores.

• Compatible with a wide range of cosmetic ingredients.

• Stable and cost-effective.

• Suitable for sensitive and acne-prone skin.

Safety and Handling

• Generally recognized as safe (GRAS) for use in cosmetics and topical pharmaceuticals.

• Well-tolerated; rare skin irritation in sensitive individuals.

• Avoid contact with strong oxidizers and acids.

• Store in a cool, dry place, away from direct sunlight.

• Use appropriate personal protective equipment (gloves, safety goggles) when handling.

Quality Assurance
Each batch is tested for purity, acid value, saponification value, and color to ensure consistent quality.